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Recombinant Rat Aquaporin-8 (Aqp8)

  • 中文名称：
    Recombinant Rat Aquaporin-8(Aqp8)
  • 货号：
    CSB-CF001972RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Aqp8
  • Uniprot No.：
  • 别名：
    Aqp8; Aquaporin-8; AQP-8
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-263
  • 氨基酸序列
    MSGEQTPMCSMDLREIKGKETNMADSYHGMSWYEQYIQPCVVELLGSALFIFIGCLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPYWVSQLFGGMIGAALAKVVSPEERFWNASGAAFAIVQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLFIGDEKTRLILKSR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water-specific channel; mercury-sensitive. It may have an important role in spermatogenesis, in fertilization, and in the secretion of pancreatic juice and saliva.
  • 基因功能参考文献：
    1. in vitro and in vivo data suggest that hepatic mtAQP8 expression is downregulated in acidosis, a mechanism that may contribute to decreased ureagenesis from ammonia in response to acidosis PMID: 26194146
    2. Downregulation of hepatocyte mtAQP8 expression leads to defective ureagenesis from ammonia in lipopolysaccharide-treated rats. PMID: 24642373
    3. The results obtained here implied that both AQP3 and AQP8 may be involved in the pathogenesis of inflammatory bowel disease. PMID: 24286754
    4. Hepatocyte mtAQP8 channels facilitate the mitochondrial uptake of ammonia and its metabolism into urea, mainly under glucagon stimulation. PMID: 23299935
    5. AQP8 plays an important role in the adaptive response of proximal tubule to acidosis possibly facilitating mitochondrial ammonia transport PMID: 22622463
    6. Down-regulated AQP8 protein expression and up-regulated AQP8 mRNA expression in the hepatocytes of pregnant rats with intrahepatic cholestasis may contribute to the pathogenesis of intrahepatic cholestasis. PMID: 18683753
    7. increased in placental labyrinth zone in maternal undernutrition PMID: 20958229
    8. these data suggest that ammonia diffusional transport is a major function for mitochondrial AQP8. PMID: 20132793
    9. Involvement of aquaporin-8 in rat testis development and spermatogenesis. PMID: 11676488
    10. Immunolocalization in kidney and other organs PMID: 11704555
    11. The cellular and subcellular distribution of AQP8 suggest physiological roles for this aquaporin in the absorption of water in the intestine and the secretion of bile and pancreatic juice in liver and pancreas. PMID: 11824790
    12. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. PMID: 11932260
    13. AQP-8 was expressed exclusively in Sertoli cells PMID: 12002438
    14. Defective expression of AQP8 water channels may contribute to bile secretory dysfunction of cholestatic hepatocytes. PMID: 12717383
    15. Glucagon induces protein kinase A and microtubule-dependent translocation of AQP8 water channels to hepatocyte canalicular plasma membrane, leading to increase in membrane water permeability. PMID: 12774023
    16. AQP8-mediated water transport may be particularly important for rapid expansions of mitochondrial volume such as those occurring during active oxidative phosphorylation and those following apoptotic signals PMID: 15749715
    17. aquaporin-8 may play a major role in water movement through the colon by acting on the apical side of the superficial cells PMID: 16177191
    18. AQP8 is expressed in the myoepithelial cells, but not in the acinar cells, of both the rat submandibular gland and parotid gland. PMID: 16311720
    19. A defective expression of canalicular AQP8 contributes as a mechanism for bile secretory dysfunction of cholestatic hepatocytes. PMID: 17110522
    20. electrically silent ammonia transport may be the main function of AQP8. PMID: 17189259
    21. Defective expression of hepatocyte AQP8 contributes to the development of bile secretory dysfunction in sepsis. PMID: 18662282
    22. Glucagon induces the gene expression of aquaporin-8 but not that of aquaporin-9 water channels in the rat hepatocyte. PMID: 19193945

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Highly expressed in sperm, pancreas and liver. Some expression has been found in salivary gland and absorptive colonic epithelial cells.
  • 数据库链接：

    KEGG: rno:29172

    STRING: 10116.ENSRNOP00000019939

    UniGene: Rn.6315