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Recombinant Rat Aquaporin-9 (Aqp9)

  • 中文名称：
    Recombinant Rat Aquaporin-9(Aqp9)
  • 货号：
    CSB-CF001973RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Aqp9
  • Uniprot No.：
  • 别名：
    Aqp9; Aquaporin-9; AQP-9; Aquaglyceroporin-9
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-295
  • 氨基酸序列
    MPSEKDGAKKSLMQRLALKSRIAKETLSEFLGTFIMIVLGCSSIAQAVLSRERFGGIITINIGFASAVVMALYVTFGISGGHINPAVSFAMCAFGRMEWFKFPFYVGAQFLGAFVGAATVFGIYYDGLMAFAGGKLLVVGENATAFIFATYPAPFISTPGAFVDQVVSTMFLLLIVFAMFDSRNLGVPRGLEPVVIGLLIIVLSCSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFTVGNNFWWIPVVGPMIGAFLGGLIYILFIQMHHSKLDPDMKAEPSENNLEKHELSVIM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines.
  • 基因功能参考文献：
    1. The upregulation of AQP9 could be involved in gluconeogenesis and co-regulated by the JNK and p38 MAPK pathway in both Types 1 and 2 DM. PMID: 29523003
    2. AQP9 expression is increased slowly and reached a peak on day 14 in optic nerve after crushing. PMID: 25479407
    3. dynamic changes in AQP9 expression, mediated in part via the p38 MAPK signal transduction pathway, may contribute to the development of cerebral oedema after brain ischaemia. PMID: 25903824
    4. we suggest that AQP9 is involved in viral tropism and pathogenesis of Herpes simplex encephalitis PMID: 25604497
    5. Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator. PMID: 25270793
    6. AQP9 was primarily localized in the membrane structures of hepatocytes and appears to be primarily responsive to glucagon induction. [aquaporin-9, AQP9] PMID: 16857339
    7. The expression of AQP9 was up-regulated in this glaucoma model and the immunoreactivities of the AQP4 and GFAP were also detected as co-localizing with AQP9 in the optic nerve region PMID: 23464865
    8. AQP9 loss adversely affects survival of retinal ganglion cells. PMID: 23506846
    9. potential role in the pathogenesis of hepatic steatosis PMID: 23415870
    10. AQP9 expression increased in the brains of injured rats & correlated with brain edema &number of injured neurons in cortical layers II/III & V/VI, striatum & hippocampal regions CA1/CA3. Inhibition improved neurobehavioral outcome. PMID: 23040263
    11. Xenopus oocytes microinjected with either AQP7 or AQP9 cRNA (cloned from mouse adipocyte and rat liver, respectively) exhibited a 10-fold increase in arsenite permeability, indicating that both aquaglyceroporins recognize and transport arsenite. PMID: 11972053
    12. The sexual dimorphism in hepatic AQP9 regulation may be ascribed to estradiol-17 beta suppressing the expression of hepatic AQP9. PMID: 22114114
    13. AQP9 immunolabeling of the RPE was increased in retinal slices from diabetic rats in comparison to slices from control rats. PMID: 21851171
    14. There was enhanced AQP9 expression in LPS-induced brain edema. PMID: 19399395
    15. Given that AQP9 presumably acts as a channel for metabolites to pass from astrocytes to neurons, the reduced expression of AQP9 at these specific sites may be implicated in the pathogenesis of glaucomatous optic neuropathy PMID: 20357197
    16. Expression of AQP9 in the developing rat epididymis is downregulated by neonatal DES, GNRHa, EE, and flutamide, and the effects mediated by estrogens can be prevented by testosterone administration. PMID: 19948840
    17. AQP-9 was localized to the microvilli of the principal cells of testis, with the most intense reaction being noted in the initial segment and cauda regions and clear cells of the cauda region. PMID: 12002438
    18. expression of aquaporin 9 is modulated by androgens in the adult rat epididymis PMID: 12021052
    19. AQP9 serves as a membrane channel in hepatocytes for glycerol and urea at physiological pH PMID: 12594337
    20. Steroid hormones regulate AQP9 expression at the mRNA and protein level and that other ovarian signals are involved in the expression of AQP5 and -8. PMID: 15647391
    21. Catecholaminergic, putatively dopaminergic, amacrine cells of the retina express aquaporin-9. PMID: 16446030
    22. AQP9 is involved in energy balance as a glycerol-lactate channel and also appears to regulate cell volume in retinal ganglion neurons. This water channel may play a key role in retinal ganglion pathology. PMID: 17337204
    23. The expression of AQP9 in glioma was studied. PMID: 17525633
    24. In brainstem slices,insulin induces a decrease in AQP9 protein levels 6 h after application, suggesting that brain AQP9 is also regulated by the insulin. This shows that brain AQP9 is affected by the concentration of insulin in a diabetic model. PMID: 18053968
    25. results suggest that extrahepatic cholestasis leads to downregulation of AQP9 in the hepatocyte basolateral plasma membrane and dysregulated aquaporin channels contribute to bile flow dysfunction of cholestatic hepatocyte PMID: 18669624
    26. The present data provide conclusive evidence for the presence of tetrameric AQP9 in brain and for the expression of AQP9 in neurons. PMID: 19115411

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Detected in testis and liver. Detected in immature spermatocytes and in interstitial Leydig cells.
  • 数据库链接：

    KEGG: rno:65054

    STRING: 10116.ENSRNOP00000021442

    UniGene: Rn.30018