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  4. Recombinant Rat C5a anaphylatoxin chemotactic receptor C5L2 (Gpr77)

Recombinant Rat C5a anaphylatoxin chemotactic receptor C5L2 (Gpr77)

  • 货号：
    CSB-CF715104RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    C5ar2; C5l2; Gpr77; C5a anaphylatoxin chemotactic receptor 2; Complement component 5a receptor 2; G-protein coupled receptor 77
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-343
  • 氨基酸序列
    MLNDTTSKDYEYEYDQEQYSDLLNVPVDCPAGNCFSNDAYLIVLLGLYSVIFLVGVPGNT LLAWVTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQKGHWPYGTAGCWLLSSIT VLSMYASVLLLTGLSGDLFLLAFRPSWKNADQRTCGVRVVQVSSWMLALLLTVPGAVYRK LLQEHYPPRLVCGTNYGGSVTAEVTITTVRFLFGFLVPLVFMASCHGILQRQMARRHWPL GTAVVVGFFICWTPFHLLRVIIAVASSHSPLLAWALEAEPLVTGLALAHSALNPIMFLYF GRKQLCKSLQAACHWALRDLQDEEESAVTKVSTSQEMVSEMPV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
  • 基因功能参考文献：
    1. Following cecal ligation and puncture-induced sepsis in rats, neutrophils demonstrated a time-dependent decrease in C5L2. PMID: 15634936
    2. A C5aR isoform expressed by glia and neurons is regulated by NA and exerts anti-inflammatory functions. Changes in C5aR isoform levels in diseased brain could therefore contribute to the progression of inflammatory damage. PMID: 15715664
    3. data provide the first evidence for a role for C5a receptor C5L2 in balancing the biological responses to Complement 5a PMID: 15784721
    4. C5L2 appears to bind complement factor C5a and its C-terminal cleavage product C5a des Arg by different mechanisms, and, unlike C5a receptor (C5aR), C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg. PMID: 17158873
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    STRING: 10116.ENSRNOP00000067721

    UniGene: Rn.127117