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Recombinant Rat Chemokine-like factor (Cklf)

  • 中文名称：
    Recombinant Rat Chemokine-like factor(Cklf)
  • 货号：
    CSB-CF005458RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Cklf
  • Uniprot No.：
  • 别名：
    Cklf; Cklf1; Chemokine-like factor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-151
  • 氨基酸序列
    MDSPQKVVDHQPFCLSLKCFVKTLRLVVTVASMIFFIVAQAPEPYIVITGFEVTIILFLI ALYMCSLDKTMRSFFWPLLDVINSVVTTLFMLIVSVSALIPETSTMIMVGGVFGFLTVIC TVADCALMCQKLRFRPHGPYQNRSATDVDDS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.; has chemotactic response in monocytes, neutrophils and lymphocytes. Binds CCR4.
  • 基因功能参考文献：
    1. Chemokine-like factor 1 (CKLF1) is involved in blood-brain barrier disruption after reperfusion. Inhibition of CKLF1 protects against cerebral ischemia by maintaining BBB integrity, possibly via inhibiting the expression of aquaporin-4 and matrix metalloproteinase-9, and increasing the expression of tight junction protein. PMID: 27283776
    2. Results suggest that CKLF1 promotes the migration of rat primary cerebral cortical neurons by the induction of actin polymerization PMID: 25144394
    3. results suggest that CKLF1 is associated with neuronal apoptosis after cerebral ischemia and reperfusion PMID: 25042180
    4. These data suggest that CKLF1 has a pivotal role in intimal hyperplasia by mediating VSMC migration. C19 was demonstrated to inhibit CKLF1-mediatated chemotaxis PMID: 23203409
    5. This study demonstrated that the expression of CKLF1 increases after focal cerebral ischemia in rat brain. PMID: 21964493

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  • 亚细胞定位：
    [Isoform CKLF1]: Secreted.; [Isoform CKLF2]: Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chemokine-like factor family
  • 组织特异性：
    Both isoforms have highest expression levels in testis with relatively lower expression level in liver, spleen, lung, brain and heart and barely detectable levels in skeletal muscle and kidney were barely detected. In most tissues, isoform CKLF2 has highe
  • 数据库链接：

    KEGG: rno:245978

    STRING: 10116.ENSRNOP00000017127

    UniGene: Rn.81197