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  4. Recombinant Rat Follicle-stimulating hormone receptor (Fshr)

Recombinant Rat Follicle-stimulating hormone receptor (Fshr)

  • 货号：
    CSB-CF009021RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Fshr; Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-692
  • 氨基酸序列
    CHHWLCHCSNRVFLCQDSKVTEIPTDLPRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEI SQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPSLRYLLISNTGIKHLPA VHKIQSLQKVLLDIQDNINIHIVARNSFMGLSFESVILWLSKNGIEEIHNCAFNGTQLDE LNLSDNNNLEELPNDVFQGASGPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLPN LDKFVTLMEASLTYPSHCCAFANLKRQISELHPICNKSILRQDIDDMTQIGDQRVSLIDD EPSYGKGSDMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAIT GNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQT GAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAF AAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRN PTIVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPIN SCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSATHNFHARKSHCSSAPRV TNSYVLVPLNHSSQN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
  • 基因功能参考文献：
    1. The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP. PMID: 28605466
    2. Data indicate that sustained follicle stimulation by luteinizing hormone (LH) decreases follicle stimulating hormone (FSH) receptor mRNA levels and FSH receptor signaling and inhibits FSH-induced follicular growth. PMID: 23709086
    3. In 20-day-old rat Sertoli cells, transmembrane cell PGs, through tethering/activation of PP2A activity exerts regulatory control on both FSH receptor/Gs coupling and ERK phosphorylation. PMID: 23500014
    4. Zuoguiyin could improve the ovarian functions during peri-menopause by up-regulating the expression of FSHR. PMID: 20535929
    5. The data suggested that, during prepubertal Sertoli cell maturation, the ability of FSH receptor to respond to FSH is significantly augmented and is associated with the robust differentiation of repopulating spermatogonia. PMID: 22850685
    6. report of inhibition of FSHR expression by WT1 in ovarian tissue; inhibition probably occurs via direct interaction with the FSHR promoter PMID: 22431408
    7. Used immunohistochemistry to study the expression of FSH-R in rat and human ductuli efferentes and the caput, corpus, and cauda epididymis, and by Western blot analysis in the caput and cauda epididymis of rat. PMID: 20467586
    8. MyH9 constitutively forms a ternary complex with FSH-R and inactive GDP-bound G alpha h. PMID: 20068007
    9. Findings support the concept that thyroid hormone regulates ovarian follicular development and promotes FSH-induced preantral follicular growth through up-regulation of FSHR, a mechanism dependent on the expression and action of oocyte-derived GDF-9. PMID: 19833718
    10. Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion PMID: 11934883
    11. differences in hydrophobic interactions between transmembrane domains 6 and 7 of the rat and human FSH receptors PMID: 12145341
    12. downregulation of FSH-FSHR PMID: 12907758
    13. FSH transcytosis across the testicular endothelial barrier is receptor-mediated and involves luminal uptake via coated pits, sorting at the level of luminal early endosomes, and transcellular transport through transcytotic tubulo-vesicular organelles PMID: 15050368
    14. OCT-1 binds within DHS3 to silence Fshr transcription, an activity that involves members of the GATA family PMID: 15817654
    15. FSH up (1.8-fold) regulates its receptor level only in the immature Sertoli cells and not in the adult. PMID: 16406266
    16. FSH receptor expression was demonstrated by RT-PCR and Northern and Western blot analyses in the cauda region of rat epididymis PMID: 16598027
    17. These data reveal that distal regulatory regions are required for appropriate temporal and spatial Fshr expression and implicate the identified evolutionary conserved regions in transcriptional regulation of Fshr. PMID: 17097219
    18. bioneutralization of FSHR has been achieved by targeting its region 285-309 PMID: 17280718
    19. Inhibin A is capable of feedback antagonizing FSH action on GCs by reducing FSHR expression at ovarian level via a short feedback loop. Transcriptional factor receptors, such as SF-1, AR and DAX-1 were involved in this regulation. PMID: 18992787
    20. Results indicate that the charged amino acids present in follicle stimulating hormone receptor peptide (20-30) are crucial for its follicle stimulating hormone antagonistic activity. PMID: 19152639

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
  • 组织特异性：
    Sertoli cells and ovarian granulosa cells.
  • 数据库链接：

    KEGG: rno:25449

    STRING: 10116.ENSRNOP00000022802

    UniGene: Rn.162843