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  4. Recombinant Rat Galanin receptor type 1 (Galr1)

Recombinant Rat Galanin receptor type 1 (Galr1)

  • 货号：
    CSB-CF730809RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Galr1; Galnr; Galnr1; Galanin receptor type 1; GAL1-R; GALR-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-346
  • 氨基酸序列
    MELAPVNLSEGNGSDPEPPAEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARS KPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLV SIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLFHRDS NQTFCWEHWPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASK KKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPLTPASFFFRITAHCLAYSNSSVNPII YAFLSENFRKAYKQVFKCRVCNESPHGDAKEKNRIDTPPSTNCTHV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
  • 基因功能参考文献：
    1. The inhibitory effect of galanin on locus coeruleus neurons is mediated by GALR1 via Gi/o proteins, which activate GIRK channels. PMID: 29852172
    2. the depression-like behavior in rats exposed to chronic mild stress is likely related to an elevated expression of Galr1 in the vPAG, suggesting that a GALR1 antagonist could have antidepressant effects. PMID: 27457954
    3. the central effect of GALR1 agonist M617 on insulin resistance in skeletal muscle and its underlying mechanisms. PMID: 27041232
    4. Suggest that excitation of central galanin receptor 1 facilitates insulin sensitivity via activation of the Akt/AS160 signaling pathway in the fat cells of type 2 diabetic rats. PMID: 27127795
    5. The sensitivity of GluA4 AMPA receptors to human galectin-1 could be enhanced by supplementation of culture media with uridine and N-acetylglucosamine (GlcNAc), precursors for hexosamine pathway that supplies UDP-GlcNAc for synthesis of oligosaccharides. PMID: 24614744
    6. Transient occlusion of the middle cerebral artery altered GalR1 gene expression in rat brain supportting the notion that GalR1 may play a role in the response of the central nervous system to injury. PMID: 22197078
    7. This study found that GALR1 mRNA was expressed in granulation tissue, including in pericytes, but only in pericytes that had been dissociated from endothelial cells. PMID: 21894515
    8. Data show that destruction of GalR1-expressing superficial dorsal horn neurons produces heat hypoalgesia, likely due to loss of GalR1-expressing excitatory interneurons leading to reduced activation of nociceptive projection neurons in response to heat. PMID: 21880366
    9. D(1)-like-Gal(1) receptor heteromers act as processors that integrate signals of two different neurotransmitters, dopamine and galanin, to modulate hippocampal cholinergic neurotransmission. PMID: 21593325
    10. Elevated expression of galanin receptors in childhood neuroblastic tumors. PMID: 11867941
    11. GALR1 expression has been detected in trigeminal ganglion cells and dental pulp. PMID: 11900829
    12. Findings suggest that the hypothalamic action of galanin on gonadotopin-releasing hormone (GnRH) secretion may pass through the specific population of galanin R1/estrogen receptor alpha neurons of the medial preoptic area in mediating estrogen action. PMID: 14764000
    13. Numerous Gal(1) mRNA-positive (+) neurons were detected in lamina (L) I-III. In addition, several Gal(1) mRNA(+) neurons were seen in deeper layers, including the ventral horns, area X, and the lateral spinal nucleus. PMID: 16626647
    14. Compared to GalR2 in regulating rodent depression-like behavior, the GalR1 receptor subtype may mediate the prodepressive effects of galanin. PMID: 18172432
    15. findings indicate that the inhibition of depolarization-evoked Ca2+ influx in myenteric neurons in culture is mediated by GalR1 and confirm the presence of functional GalR1 in the myenteric plexus PMID: 19006083

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Spinal cord, small intestine, Rin14B insulinoma cells and several brain regions, particularly ventral hippocampus, amygdala, supraoptic nucleus, hypothalamus, thalamus, lateral parabrachial nucleus and locus coeruleus.
  • 数据库链接：

    KEGG: rno:50577

    STRING: 10116.ENSRNOP00000022400