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  4. Recombinant Rat Gap junction alpha-3 protein (Gja3)

Recombinant Rat Gap junction alpha-3 protein (Gja3)

  • 中文名称：
    大鼠Gja3重组蛋白
  • 货号：
    CSB-CF009446RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Gja3
  • Uniprot No.：
  • 别名：
    Gja3; Cxn-46; Gap junction alpha-3 protein; Connexin-46; Cx46
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-416
  • 氨基酸序列
    GDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGC ENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEELLRRDNPQH GRGREPMRTGSPRDPPLRDDRGKVRIAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFQL QPLYRCDRWPCPNTVDCFISRPTEKTIFVIFMLAVACASLVLNMLEIYHLGWKKLKQGVT NHFNPDASEVRHKPLDPLSEAANSGPPSVSIGLPPYYTHPACPTVQGKATGFPGAPLLPA DFTVVTLNDAQGRGHPVKHCNGHHLTTEQNWASLGAEPQTPASKPSSAASSPHGRKGLTD SSGSSLEESALVVTPEGEQALATTVEMHSPPLVLLDPERSSKSSSGRARPGDLAI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Structural component of lens fiber gap junctions (Probable). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (Probable).
  • 基因功能参考文献：
    1. These results suggest that the C-terminal region of rCx46 up to A311 (rCx46(35.3)) is necessary for its correct compartmentalization and internalization in the form of annular junctions PMID: 23065326
    2. Cx43 and Cx46 have novel functions in regulating each other's expression and turnover in a reciprocal manner in addition to their conventional roles as gap junction proteins in lens cells. PMID: 21606502
    3. Data provide evidence that the activation and inhibition of PKC affect the rCx46-mediated membrane conductance as well as the voltage-dependent current inactivation in an inverse manner. PMID: 9683738
    4. A non-conservative missense mutation, Glu42Lys, was found in the gene of the rats with congenital cataracts; this mutation was likely to be responsible for the pathogenesis PMID: 16271086
    5. We propose that CKII-dependent phosphorylation in the C-terminus accelerates formation of rCx46-connexons. PMID: 18668357
    6. Modulation of Cx46 hemichannels by nitric oxide. PMID: 19357237

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Alpha-type (group II) subfamily
  • 组织特异性：
    Detected in eye lens (at protein level). Most abundant in lens, but also present in heart and kidney.
  • 数据库链接：

    KEGG: rno:79217

    STRING: 10116.ENSRNOP00000011699

    UniGene: Rn.10345