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  4. Recombinant Rat Growth hormone receptor (Ghr)

Recombinant Rat Growth hormone receptor (Ghr)

  • 货号：
    CSB-CF009411RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ghr; Growth hormone receptor; GH receptor; Somatotropin receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-638
  • 氨基酸序列
    FPGSGATPATLGKASPVLQRINPSLRESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECPDYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLLNISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLYSLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEDFRFPWFLIIIFGIFGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYKPDFYNDDSWVEFIELDIDDADEKTEESDTDRLLSDDQEKSAGILGAKDDDSGRTSCYDPDILDTDFHTSDMCDGTSEFAQPQKLKAEADLLCLDQKNLKNSPYDASLGSLHPSITLTMEDKPQPLLGSETESTHQLPSTPMSSPVSLANIDFYAQVSDITPAGGVVLSPGQKIKAGLAQGNTQLEVAAPCQENYSMNSAYFCESDAKKCIAAAPHMEATTCVKPSFNQEDIYITTESLTTTARMSETADTAPDAEPVPDYTTVHTVKSPRGLILNATALPLPDKKKFLSSCGYVSTDQLNKIMQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
  • 基因功能参考文献：
    1. receptor crosstalk between growth hormone and insulin signal in rats born small for gestational age with catch-up growth PMID: 24963636
    2. The growth hormone receptor expression in the brain was lower during fetal period than in adults, while in the pituitary gland, the expression is markedly higher in fetuses, suggesting a yet unknown role of growth hormone in the development of this organ. PMID: 21177131
    3. Growth hormone receptor mRNA levels decrease in hypothalamus during normal pregnancy while growth hormone expression rises in the pituitary. PMID: 20814072
    4. Data show that TrCP acts in an early stage of cargo selection: both TrCP silencing and mutation of the ubiquitin-dependent endocytosis motif force the GHR to recycle between endosomes and the plasma membrane. PMID: 21195069
    5. GH and its receptor have roles in injury-induced neurogenesis PMID: 19524466
    6. gene expression of GH and GHR mRNA in isolated oocytes and follicular wall cells of pre-antral follicles; localisation of immunoreactive IGF-I, IGFR, GH and GHR proteins in ovarian sections of 10-day-old rats PMID: 11964096
    7. localization in growth plate PMID: 12162495
    8. exerts divergent effects on STAT5-mediated transcription depending on its cellular location PMID: 12488452
    9. findings demonstrate the interaction of cytokine-induced Src homology domain 2 protein(CIS) with the growth hormone receptor in vivo and suggest that CIS may enhance degradation of the receptor by a proteasomal pathway PMID: 12586763
    10. data suggest that muscle atrophy is associated with a muscle fiber type-specific growth hormone receptor mRNA up-regulation mechanism PMID: 12865352
    11. The growth plate distribution of IGF-IR and GHR mRNA implies distinct roles for circulating IGF-I vs. paracrine produced IGF-I. PMID: 15609625
    12. GH receptor in visceral sensory and motor structures is consonant with a role of GH in the regulation of food intake and energy homeostasis. Its presence in the spinal dorsal horn indicates a role for GH in the initial processing of fine afferent input. PMID: 15664698
    13. The growth hormone(GH)-responsive rat liver cell line CWSV-1 was used to investigate the role of CIS and the proteasome in GH-induced GHR internalization. PMID: 16154995
    14. In the intrauterine growth restricted rat at one year of age, levels of pituitary GH, GH-R and GHRH-R relative gene expression were increased. PMID: 16867182
    15. acetaminophen indirectly stimulates spinal (5-HT)1A receptors, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor,(IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of sst3R mRNA PMID: 17088403
    16. results suggest that the acquisition of mechanisms responsible for the regulation of GH or GHRH-receptor transcription by T3 may be involved in the process of functional development of GH cells PMID: 17090972
    17. These findings indicate that the heterologous reduction of GHR by insulin occurs via transcriptional downregulation, and the homologous reduction of GHR by GH occurs via a different mechanism. PMID: 17658679
    18. Insulin signaling via either the PI-3 kinase or MEK/ERK pathway may result in partial reduction of GHR gene expression, whereas signaling via both pathways may be required to achieve the full insulin effect. PMID: 18040895

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 1 subfamily
  • 组织特异性：
    Highest expression in liver. Also expressed in heart, kidney and muscle.
  • 数据库链接：

    KEGG: rno:25235

    STRING: 10116.ENSRNOP00000044119

    UniGene: Rn.2178