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  4. Recombinant Rat Mucin-4 (Muc4)

Recombinant Rat Mucin-4 (Muc4)

  • 货号：
    CSB-CF733957RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Muc4
  • Uniprot No.：
  • 别名：
    Muc4; Smc; Mucin-4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Pre-sialomucin complex; pSMC; Sialomucin complex; Testis mucin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    1616-2344
  • 氨基酸序列
    DPHITTLDNAKYTFNGLGYFLLVQAQDRNSSFLLEGRTAQTDSANATNFIAFAAQYNTSS LKSPITVQWFLEPNDTIRVVHNNQTVAFNTSDTEDLPVFNATGVLLIQNGSQVSANFDGT VTISVIALSNILHASSSLSEEYRNHTKGLLGVWNDNPEDDFRMPNGSTIPSNTSEETLFH YGMTSETNGIGLLGVRTDPLPSEFTPIFLSQLWNKSGAGEDLISGCNEDAQCKFDILATG NRDIGQSTNSILRTFRHVNGTLNQYPPPIHYSSKIQAYKGREQWPLRSPATLRMSYSASP TSAVAFELFENGSLHVDTNIPRRTYLEILARDVKTNLSSVLQPETVACFCSKEEQCLYNE TSKEGNSSTEVTSCKCDGNSFGRLCEHSKDLCTEPCFPNVDCIPGKGCQACPPNMTGDGR HCVAVEISEFCQNHSCPVNYCYNHGHCDISGPPDCQPTCTCAPAFTGNRCFLAGNNFTPI IYKELPLRTITLSLREDENASNADVNASVANVLENLDMRAFLSNSLVELIRTSPGAPVLG KPIHHWKVVSHFKYRPRGPLIHYLNNQLISAVMEAFLLQARQERRKRSGEARKNVRFFPI SRADVQDGMALNLSMLDEYFTCDGYKGYHLVYSPQDGVTCVSPCSEGYCHNGGQCKHLPD GPQCTCATFSIYTSWGERCEHLSVKLGAFFGILFGALGALLLLAILACVVFHFCGCSMNK FSYPLDSEL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.
  • 亚细胞定位：
    [Mucin-4 beta chain]: Cell membrane; Multi-pass membrane protein.; [Mucin-4 alpha chain]: Secreted.
  • 组织特异性：
    Expression is developmentally regulated in the mammary gland, dramatically increases in the lactating gland compared with the virgin mammary gland, while decreasing again during mammary gland involution. Expressed in 13762 ascites cells. Overexpressed in