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  4. Recombinant Rat Myelin proteolipid protein (Plp1)

Recombinant Rat Myelin proteolipid protein (Plp1)

  • 货号：
    CSB-CF018202RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Plp1
  • Uniprot No.：
  • 别名：
    Plp1; Plp; Myelin proteolipid protein; PLP; Lipophilin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-277
  • 氨基酸序列
    GLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYL INVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQ KGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTW TTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFI AAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
  • 基因功能参考文献：
    1. PLP and DM-20 mRNA expression is restricted to oligodendrocyte-lineage cells PMID: 26563642
    2. Protein levels of PLP were significantly greater in orbital frontal cortex (OFC) but not dorsal striatum (dSTR) of females as compared to males, suggesting that myelination is increased in OFC but similar in dSTR of females as compared to males PMID: 26002313
    3. Perinatal methylmercury exposure reduces the expression of Plp1 and Cnp splice variants in cerebellum of rat pups. PMID: 25936639
    4. PLP localization in the cell membrane is altered in myelination-inhibiting fibronectin substrates. PMID: 25003183
    5. PLP transport to the myelin membrane proceeds via a transcytotic mechanism mediated by sulfatide with a conformational alteration and transient partitioning of PLP into distinct membrane microdomains involved in biosynthetic and transcytotic transport PMID: 25368380
    6. Differences in myelin and disparate distributions of myelin protein markers in comparison to wild-type controls are observed in PLP1 transgenic rats. PMID: 21784154
    7. Mutation in the myelin proteolipid protein gene alters BK and SK channel function in the caudal medulla. PMID: 19808102
    8. Proteolipid protein gene modulates viability and phenotype of neurons; PLP-specific products contributed to decreased neuron survival. PMID: 11880506
    9. We conclude that an ESE in exon3B regulates PLP 5' donor site selection and that ASF/SF2 protein participates in the regulation of PLP alternative splicing in oligodendrocytes. PMID: 16288477

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  • 相关疾病：
    Defects in Plp1 are the causee of the dysmyelinating disease MD.
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Myelin membrane.
  • 蛋白家族：
    Myelin proteolipid protein family
  • 数据库链接：

    KEGG: rno:24943

    STRING: 10116.ENSRNOP00000003283

    UniGene: Rn.4550