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  4. Recombinant Rat Neuromedin-U receptor 2 (Nmur2)

Recombinant Rat Neuromedin-U receptor 2 (Nmur2)

  • 货号：
    CSB-CF875367RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Nmur2; Tgr1; Neuromedin-U receptor 2; NMU-R2; G-protein coupled receptor TGR-1; G-protein-coupled receptor FM-4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-395
  • 氨基酸序列
    MGKLENASWIHDPLMKYLNSTEEYLAHLCGPKRSDLSLPVSVAYALIFLVGVMGNLLVCM VIVRHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEIYEMWHNYPFLFGPVGCYFKTALFET VCFASILSVTTVSVERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIK FQHFPNGSSVPGSATCTVTKPMWVYNLIIQATSFLFYILPMTLISVLYYLMGLRLKRDES LEANKVAVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVEEWTESLAAVFNLI HVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPTCKWCHPRHRPQGPPAQKIIFLTE CHLVELTEDAGPQFPGQSSIHNTNLTTAPCAGEVP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the neuromedin-U and neuromedin-S neuropeptides.
  • 基因功能参考文献：
    1. Results demonstrate that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods without disrupting feeding behavior associated with non-obesogenic standard chow PMID: 24269937
    2. Results show that central-activation of neuromedin U2 receptor markedly reduced sleep duration and disrupted the mechanisms underlying NREM-REM sleep transitions. PMID: 21296417
    3. These results suggest that NMU modulates the function of the PVN putative parvocellular neurons and is involved in the regulation of OTergic and VPergic neurons by enhanced HCN ion channels activity via NMU-receptor 2. PMID: 15631899
    4. Expression of NMS and NMU2R genes was detected at the hypothalamus along postnatal development, with significant fluctuations of their relative levels (maximum at prepubertal stage and adulthood). PMID: 17110433
    5. endogenous rat NmU receptors couple to both Galpha(q/11) and Galpha(i) G-proteins. Challenge of either circular or longitudinal rat isolated colonic smooth muscle. preparations with NmU resulted in robust contractions PMID: 18180374
    6. cultured rat calvarial osteoblast-like cells are provided with NMUR2, the receptor isoform typical for the central nervous system PMID: 18698496

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    The highest level is detected in the uterus. In the central nervous system, high expression levels were found in the hypothalamus and moderate levels in both the medulla oblongata and spinal cord. Expressed in the hypothalamic paraventricular nucleus (PVN
  • 数据库链接：

    KEGG: rno:64042

    STRING: 10116.ENSRNOP00000018967

    UniGene: Rn.160579