Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Rat P2Y purinoceptor 2 (P2ry2)

Recombinant Rat P2Y purinoceptor 2 (P2ry2)

  • 货号：
    CSB-CF017334RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    P2ry2; P2ru1; P2Y purinoceptor 2; P2Y2; ATP receptor; P2U purinoceptor 1; P2U1; Purinergic receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-374
  • 氨基酸序列
    MAAGLDSWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLC RLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYAQGDHWPFSTVLCKLVRFLFYTNLYCS ILFLTCISVHRCLGVLRPLHSLSWGHARYARRVAAVVWVLVLACQAPVLYFVTTSVRGTR ITCHDTSARELFSHFVAYSSVMLGLLFAVPFSIILVCYVLMARRLLKPAYGTTGLPRAKR KSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKITRPLASANSCL DPVLYFLAGQRLVRFARDAKPATEPTPSPQARRKLGLHRPNRTDTVRKDLSISSDDSRRT ESTPAGSETKDIRL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
  • 基因功能参考文献：
    1. study suggests that P2Y2R is involved in regulation of bone turnover PMID: 28828576
    2. Activation of renal medullary P2Y2/P2Y4 receptors promotes ET-1-dependent natriuresis in ovariectomized rats. PMID: 28468962
    3. Uridine triphosphate regulates the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells via the P2Y2 receptor. PMID: 26531757
    4. Myocardial expression of the protective P2Y2 receptor subtype is decreased in coronary ischemia-reperfusion injury. PMID: 26070527
    5. in 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by R2Y2 receptors. R2Y4 receptors took part in the realization of negative inotropic response to uridine triphosphate in all age groups PMID: 24771361
    6. The results of this study suggest that inhibition of P2Y receptors leads to down-regulation of ERK-mediated phosphorylation and increase of the expression of I(A)-related Kv channels in trigeminal ganglion neurons. PMID: 24642246
    7. Thus, P2Y2R activation protects cardiomyocytes from hypoxia in vitro and reduces post-ischemic myocardial damage in vivo. PMID: 23828651
    8. UTP-induced migratory responses required for salivary gland acinar cell self-organization are mediated by the P2Y2R. PMID: 24760984
    9. This is the first report of selective coupling of one type of SK channel to purinergic stimulation of microglia, transactivation of KCa3.1 channels by CRAC/Orai1. PMID: 23620825
    10. A developmental function of P2Y2R in promoting synaptic gene expression. PMID: 23592515
    11. A significant cellular coexpression of P2X3 and P2Y2 in rat DRG neurons. PMID: 23249537
    12. Carotid body type II cells may function as ATP amplifiers during chemotransduction via paracrine activation of P2Y2Rs and Panx-1 channels. PMID: 22733659
    13. Uridine adenosine tetraphosphate induced Nox1-dependent reactive oxygen species generation, which further stimulated MCP-1 formation via MAPK phosphorylation in vascular smooth muscle cells. This process requires the activation of P2Y(2). PMID: 21487675
    14. Amyloid precursor protein (APP) production and secretion are regulated by activation of P2Y2/4 receptors coupled to protein kinase signaling pathways, in a demonstration using astrocytes as a potential source of APP. PMID: 21300137
    15. ATP induces [Ca(2+)](i)-dependent contraction in intestinal subepithelial myofibroblasts, which is mediated through the P2Y(2) receptor PMID: 21296070
    16. Therefore, the spatio-temporal pattern of P2Y(2) gene expression after spinal cord injury suggests a role in the pathophysiology response generated after trauma. PMID: 20619335
    17. Data suggest that increased production of PGE2 by the medullary collecting duct in postobstructive uropathy may be due to increased expression and activity of the P2Y2 receptor. PMID: 20007349
    18. ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling PMID: 12210747
    19. immunostaining of pancreas from streptozotocin-diabetic rats revealed P2Y1 and P2Y2 receptor expression in pancreatic duct cells and P2X1, P2X2, P2Y1 and P2Y2 receptor expression in small blood vessels. PMID: 12850289
    20. Quiescent hepatic stellate cells expressed the P2Y subtypes P2Y(2) and P2Y(4). PMID: 14764443
    21. ATP regulates postsynaptic gene expressions via a common pathway triggered by the activation of P2Y1 and P2Y2 receptors at the nmjs. PMID: 15258260
    22. Because virtually all renal cells release ATP, the observed alterations in P2Y2-R expression in the inner medulla in hydrated and dehydrated states may constitute a novel mechanism of purinergic modulation of collecting duct function. PMID: 15687250
    23. altered expression of P2Y2-R in hydrated and dehydrated states is associated with corresponding changes in P2Y2-R-mediated PGE2 release by the kidney collecting duct PMID: 15840771
    24. study shows that there are different interactions between the subtypes of P2Y purinergic receptors and different Ca(2+)-activated K+ channels PMID: 16075244
    25. P2Y(2)Rs and their associated signaling pathways may be important factors regulating astrogliosis in brain disorders PMID: 16135088
    26. P2Y(2) has a role as a morphogen receptor that potentiates neurotrophin signaling in neuronal development and regeneration PMID: 16365320
    27. The results, which define a novel mechanism for inhibition of apoptosis, implicate parallel, interacting systems--extracellular nucleotides/P2Y2 receptors and neurotrophin/TrkA--to sustain neuronal survival. PMID: 16597733
    28. novel signaling pathway may be involved in the increase in MCP-1 mRNA by activation of P2Y(2) receptors in alveolar and peritoneal macrophage PMID: 17947675
    29. Cultured rat urothelial cells functionally express P2Y(2)/P2Y(4) receptors. PMID: 18216148
    30. muscarinic stimulation-induced Cl(-) reabsorption occurs through basal CFTR activity and that this is regulated by P2Y(2) receptors PMID: 18337312
    31. Stimulatory effect of lipopolyssaccharides as in ATP-dependent upregulation in alveolar cells of P2Y2 receptor. PMID: 18689605
    32. Results suggest that the amount and property of P2Y(2) receptors were changed by cell density, resulting in different patterns observed for internal calcium mobilization . PMID: 19140137
    33. transgenic rat model of P2Y(2)R overexpression may prove useful for linking P2Y(2)R upregulation with chronic inflammatory diseases, neurodegenerative diseases and Sjogren's syndrome PMID: 19155635
    34. P2Y2 and P2Y4 receptors in granulosa cells modulate Cl- permeability by regulating Ca2+-release. PMID: 19191015
    35. P(2y2) and/or P(2y4) receptors may be involved in the enhanced purinergic signaling in lithium induced nephrogenic diabetes insipidus PMID: 19244398

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: rno:29597

    STRING: 10116.ENSRNOP00000026115

    UniGene: Rn.11102