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  4. Recombinant Rat Phospholemman (Fxyd1)

Recombinant Rat Phospholemman (Fxyd1)

  • 货号：
    CSB-CF009089RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Fxyd1; Plm; Phospholemman; FXYD domain-containing ion transport regulator 1; Sodium/potassium-transporting ATPase subunit FXYD1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    21-92
  • 氨基酸序列
    EAPQEPDPFTYDYHTLRIGGLTIAGILFILGILIILSKRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.
  • 基因功能参考文献：
    1. Data suggest Ncx1 (sodium-calcium exchanger 1) is substrate-specifying Pp1c (protein phosphatase 1c) regulator protein, regulating Ncx1 activity via Ser-68-Plm dephosphorylation in cardiomyocytes; Plm/Ncx1/Pp1c complex is up-regulated in heart failure. PMID: 26668322
    2. PLM exists as a pump-inhibiting monomer and an unassociated oligomer. PMID: 23532852
    3. Chronic nicotine modifies skeletal muscle Na,K-ATPase activity through its interaction with the nicotinic acetylcholine receptor and phospholemman. PMID: 22442718
    4. role of protein phosphatase-1 on phospholemman phosphorylation and Na/K-ATPase activity in cardiomyocytes PMID: 21849407
    5. palmitoylation of PLM controls its turnover, and palmitoylated PLM inhibits the sodium pump. PMID: 21868384
    6. Report altered expression of Na(+)-K(+) pump subunits, FXYD1 and NHE1 depending on training status, intensity and muscle type. PMID: 21325644
    7. hypertonic activation of this protein in solitary rat hepatocytes in primary culture PMID: 12606048
    8. Expression in the extraglomerular mesangial cells and juxtaglomerular apparatus arterioles PMID: 12657562
    9. Myocardial ischemia-induced phosphorylation of phospholemman directly activates cardiac Na/K-ATPase. PMID: 14597563
    10. PLM phosphorylation at Ser68 may be involved in cAMP- and/or protein kinase C-dependent regulation of cardiac contractility. PMID: 15653756
    11. In skeletal muscle, PLM appears to be a protein integral to the Na+-K+-ATPase(NKA) complex, and PLM has the potential to modulate NKA in an isoform-specific and muscle type-dependent manner in aging and after exercise training. PMID: 15961612
    12. These results suggest that FXYD1 contributes to facilitating the advent of puberty by maintaining GnRH neuronal excitability to incoming transsynaptic stimulatory inputs. PMID: 19187398

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  • 亚细胞定位：
    Cell membrane, sarcolemma; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Membrane, caveola. Cell membrane, sarcolemma, T-tubule.
  • 蛋白家族：
    FXYD family
  • 组织特异性：
    In adult brain, highest levels are found in the cerebellum and in the lateral, third and fourth ventricles of the choroid plexus (at protein level). Also detected in cells of a portion of the ependymal lining of the lateral ventricle on its rostral surfac
  • 数据库链接：

    STRING: 10116.ENSRNOP00000028624

    UniGene: Rn.3828