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  4. Recombinant Rat Potassium voltage-gated channel subfamily A member 5 (Kcna5)

Recombinant Rat Potassium voltage-gated channel subfamily A member 5 (Kcna5)

  • 货号：
    CSB-CF012010RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Kcna5
  • Uniprot No.：
  • 别名：
    Kcna5; Potassium voltage-gated channel subfamily A member 5; RCK7; RK4; Voltage-gated potassium channel subunit Kv1.5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-602
  • 氨基酸序列
    MEISLVPLENGSAMTLRGGGEAGASCVQTPRGECGCPPTSGLNNQSKETLLRGRTTLEDA NQGGRPLPPMAQELPQPRRLSAEDEEGEGDPGLGTVEEDQAPQDAGSLHHQRVLINISGL RFETQLGTLAQFPNTLLGDPAKRLHYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPV NVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSA RAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGINGSVSGALSSG PTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDVVAIFPYF ITLGTELAEQQPGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASM RELGLLIFFLFIGVILFSSAVYFAEADNHGSHFSSIPDAFWWAVVTMTTVGYGDMRPITV GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGNQRRESGLDTG GQRKVSCSKASFCKTGGSLESSDSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTSRET DL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets.
  • 基因功能参考文献：
    1. Ang II selectively stimulates degradation of KV1.5 channels to reduce functional KV1.5 channel surface abundance in mesenteric artery myocytes PMID: 27958660
    2. Ang II upregulates the expression of Kv1.5, SAP97 and TGF-beta1 in neonatal rat atrial myocytes. PMID: 25451261
    3. AMPK selectively inhibits Kv1.5 in pulmonary arterial myocytes PMID: 27062501
    4. This study demonstrates for the first time an altered gene and protein expression of NFATc2 and KV1.5 in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Upregulation of NFATc2 with concomitant downregulation of KV1.5 channels may contribute to abnormal vascular remodeling. PMID: 27522126
    5. H2S downregulates Ang II-induced atrial Kv1.5 expression by attenuating Nox4-related ROS-triggered P-Smad2/3 and P-ERK 1/2 activation during atrial fibrillation PMID: 28011270
    6. Data indicate that intravascular pressure-induced membrane depolarization selectively increased voltage-dependent potassium channels K(v)1.5 surface abundance to increase K(v) currents in arterial myocytes, which would limit vasoconstriction. PMID: 26286025
    7. KV1.5, a DPO-1-sensitive KDR channel, plays a major role in determining microvascular tone and the response to vasoconstrictors and vasodilators. PMID: 25808400
    8. The inhibited expression of Kv1.5 in pulmonary artery smooth muscle cells contribute to the development of exaggerated chronic hypoxia pulmonary hypertension in intrauterine growth retardation rats during adulthood. PMID: 24077947
    9. Kv1.5 may play an important role in oxidative vascular endothelial injury PMID: 23185428
    10. Puerarin upregulated Kv1.5 expression, decreased the proliferation and increased the apoptosis induced by hypoxia in pulmonary artery smooth muscle cells. PMID: 22357486
    11. and immunocytochemistry experiments revealed an association between K(v)1.5, K(v)beta1.3, the receptor for activated C kinase (RACK1), PKCbetaI, PKCbetaII, and PKCtheta. PMID: 22547057
    12. In rat bronchial smooth muscle cells PKC activation inhibits K(V) currents and down-regulates the expression of K(V)1.5. PMID: 12715100
    13. BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles. PMID: 22052159
    14. Augmenter of liver regeneration might increase the expression of HIF-1alpha and K(+) channels and decrease intracellular free Ca(2+), thereby inhibiting arterial contraction and promoting kidney perfusion immediately after OLT. PMID: 21365420
    15. Kv1.5 and Kv2.1 account for virtually all the O2-sensitive current in resistance pulmonary arteries. PMID: 15217912
    16. a pathway for Kv1.5 internalization from the cell surface involving early endosomes, followed by later trafficking by the dynein motor along microtubules. PMID: 16051887
    17. over-expression of Kv1.5 induces short action potential duration and triggers activity in rat cardiomyocytes PMID: 16713996
    18. In summary, we reported for the first time a heterogeneous function and expression of Kv1 alpha-subunits in rat coronary myocytes isolated from RCA or LCA. PMID: 16731637
    19. Kv1.5 is not present in caveolae of rat and canine heart. PMID: 17054951
    20. Kv1.5 subunits are concentrated in cholesterol-enriched membrane microdomains distinct from caveolae. PMID: 17525113
    21. heterogeneity of pulmonary artery smooth muscle cells may partially be related to different expression levels and functional sensitivity of Kv channels to hypoxia PMID: 17526598
    22. Generalized inhibition of nuclear factor of activated T cells (NFAT) in circulating cells by cyclosporine therapy upregulates Kv1.5 in isolated pulmonary artery in vivo and reverses established rat pulmonary hypertension. PMID: 17596340
    23. Our results show that Kcna5 promoter activity in vascular smooth muscle is critically dependent on Sp1 regulation via CACCC box motifs and identify mechanisms that potentially influence the expression of K(V)1.5 channel expression. PMID: 17660393
    24. Caveolin regulates kv1.5 trafficking to cholesterol-rich membrane microdomains. PMID: 18045854
    25. These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1. PMID: 18065659
    26. Hypoxia inhibits K(V)1.5 channel through 15-lipoxygenase /15-HETE pathway. PMID: 18984061
    27. Results suggest that cholesterol regulates Kv1.5 channel expression by modulating its trafficking through the Rab11-associated recycling endosome. PMID: 19706553

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.5/KCNA5 sub-subfamily
  • 组织特异性：
    Expressed equally in atrium, ventricle, aorta and skeletal muscle. Weaker expression in brain.
  • 数据库链接：

    KEGG: rno:25470

    STRING: 10116.ENSRNOP00000026691

    UniGene: Rn.162789