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  4. Recombinant Rat Prostaglandin F2-alpha receptor (Ptgfr)

Recombinant Rat Prostaglandin F2-alpha receptor (Ptgfr)

  • 货号：
    CSB-CF018979RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ptgfr; Prostaglandin F2-alpha receptor; PGF receptor; PGF2-alpha receptor; Prostanoid FP receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-366
  • 氨基酸序列
    MSINSSKQPASSAAGLIANTTCQTENRLSVFFSIIFMTVGIVSNSLAIAILMKAYQRFRR KSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFDQSNILCSVFGISMVFSGL CPLFLGSTMAIERCIGVTNPLFHSTKITSKHVKMILSGVCMFAVFVALLPILGHRDYQIQ ASRTWCFYNTEHIEDWEDRFYLLFFSSLGLLALGISFSCNAVTGVTLLRVKFRSQQHRQG RSHHLEMVIQLLAIMCVSCVCWSPFLVTMANIAINGNNSPVTCETTLFALRMATWNQILD PWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKENQQA SSEAGL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.
  • 基因功能参考文献：
    1. Prostaglandin F-receptor antagonist AS604872 exacerbates vascular inflammation in hypertensive animals, facilitating intracranial aneurysm formation and aortic dissection. PMID: 25341845
    2. There was an increase rat prostaglandin F receptor expression in rat uterus with advancing gestation, a marked elevation of expression at term, and a concominant decrease during the postpartum period. PMID: 24136214
    3. Data found that FP localizes in neuronal somata and dendrites but not in ependymal cells, tanycytes, or endothelial cells. Immunohistochemical analysis of serial sections showed the colocalization of FP and PGFS I. PMID: 19429887
    4. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. PMID: 11832489
    5. Activity of PGF(2alpha) by putative pacemaker cells underlies the generation of calcium action potentials in normal rat kidney monolayers. PMID: 18703136

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Highest expression in pregnant ovary. Also found in a low extent in the kidney. In the brain, expressed in astrocytes and oligodendrocytes, and meningeal fibroblasts, but not in migroglia cells.
  • 数据库链接：

    KEGG: rno:25652

    STRING: 10116.ENSRNOP00000065253

    UniGene: Rn.97602