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  4. Recombinant Rat Protein lifeguard 2 (Faim2)

Recombinant Rat Protein lifeguard 2 (Faim2)

  • 货号：
    CSB-CF007971RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Faim2
  • Uniprot No.：
  • 别名：
    Faim2; Lfg; Lfg2; Nmp35; Protein lifeguard 2; Fas apoptotic inhibitory molecule 2; Neural membrane protein 35
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-316
  • 氨基酸序列
    MTQGKLSVANKAPGTEGQQQANGEKKDAPAVPSAPPSYEEATSGEGLKAGAFPQGPTAVP LHPSWAYVDPSSSSGYEGGFPAGHHELFSTFSWDDQKVRQLFIRKVYTILLVQLLVTLAV VALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMA YLTGMLSSYYNTTSVLLCLGITALVCLSVTIFSFQTKFDFTSCHGVLFVLLMTLFFSGLL LAILLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDI IYIFTFFLQLFGTNRE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
  • 基因功能参考文献：
    1. Data show that NMP35 supports axonal growth, and overexpression of an axonally targeted NMP35 mRNA is sufficient to increase axonal outgrowth. PMID: 23097042
    2. expression of Etv5, Faim2, Fto, Negr1 but not Sh2b1 is affected by nutritional state in these two areas, and the relationship between nutritional state and expression levels of obesity-associated genes in two brain areas relevant to feeding. PMID: 22627920
    3. NMP35 protein occurs throughout the brain and spinal cord, especially in dendrites of several neuronal cell types and in the surrounding neuropil. NMP35 co-localizes with the glutamate receptor GluR2 and the presynaptic vesicle protein synaptophysin. PMID: 12414123
    4. LFG mediated the FasL resistance of cerebellar granular cells to apoptosis PMID: 16033886
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane.
  • 蛋白家族：
    BI1 family, LFG subfamily
  • 组织特异性：
    Expressed at high levels on dendrites and to a lesser extent on the soma and axons of neurons in various regions of brain.
  • 数据库链接：

    KEGG: rno:246274

    STRING: 10116.ENSRNOP00000039775

    UniGene: Rn.162026