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  4. Recombinant Rat Proto-oncogene Mas (Mas1)

Recombinant Rat Proto-oncogene Mas (Mas1)

  • 货号：
    CSB-CF013505RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Mas1; Mas; Mas-1; Proto-oncogene Mas
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-324
  • 氨基酸序列
    MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRM RRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLY LLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSQ SDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFA MPMRVLYLLYYEYWSTFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTR AFKDEMQPRRQEGNGNTVSIETVV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
  • 基因功能参考文献：
    1. Renal AT1 receptor activation, as well as Mas receptor activation, plays an essential role in mediating Ang-(1-7)-induced natriuresis and diuresis. PMID: 28940861
    2. ACE2Ang (17)MasR axis may present a potential protective role in the development of myocardial remodeling. PMID: 28656296
    3. Ang-(1-5) is an active mediator of renin-angiotensin system to stimulate ANP secretion via Mas R and PI3K-Akt-NOS pathway. PMID: 27660028
    4. Mas receptor antagonist abolished relaxation while bradykinin receptor antagonist only slightly reduced it, suggesting that bradykinin-induced vasorelaxation is regulated also by other mechanisms than the classical BR1/BR2 pathway. PMID: 27628189
    5. AngII/AT1R and Ang-(1-7)/Mas1 receptor signaling converge on anessential common pathway of importance for both angiogenesis and vasodilation in the renin-angiotensin system involving ERK1/2 and p38MAPK signaling. PMID: 28082260
    6. valsartan attenuates neointimal hyperplasiain balloon-injured rat aortic arteries through activation of the ACE2-angiotensin-(1-7)-Mas axis as well as inhibition of the ACE-angiotensin II-AT1 and p-ERK pathways. PMID: 27050934
    7. enhancing Ang-(1-7)-Mas-R-nNOS system is likely to be beneficial in preventing against cardiovascular and cerebrovascular dysfunction. PMID: 27960152
    8. results demonstrated that renovascular hypertension increased Mas receptors expression and nitric oxide production in the rats carotid which, consequently increased Ang-(1-7)-vasorelaxant response. PMID: 26256416
    9. It seems that co-blockade of all AT1R, AT2R, and MasR may alter Renal blood flow/kidney weight in male more than in female rats. These findings support a crosstalk between MasR and Ang II receptors in renal circulation. PMID: 27030624
    10. Suggest role for angiotensin-(1-7)/Mas receptor/NO pathway in mediating the cardioprotective effects of pacing postconditioning. PMID: 26519026
    11. Actually the peptides Ang-(1-7) have been involved in modulating pain sensitivity. This modulation appear be dependent of its interaction with Mas receptor PMID: 25895850
    12. Suppression of ACE-ANG II axis in the circulation and kidney tissue, combined with augmentation of the intrarenal vasodilator ACE2-ANG 1-7 axis, is the main mechanism responsible for blood pressure-lowering effects of chronic hypoxia in mRen2 rat. PMID: 25194129
    13. Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. PMID: 25194138
    14. ACE2-angiotensin-(1-7)-Mas axis significantly inhibits pancreatitis in response to decreased inflammatory factors by the activation of endothelial nitric oxide synthase and NO signaling pathways. PMID: 25426615
    15. Participation of AT1 and Mas receptors in the modulation of inflammatory pain. PMID: 25169953
    16. Role of Mas receptor antagonist (A779) on pressure diuresis and natriuresis and renal blood flow in the absence of angiotensin II receptors type 1 and 2 in female and male rats PMID: 25371522
    17. Angiotensin-(1-7) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas/eNOS-dependent pathway PMID: 24824997
    18. Western blot analysis revealed that AT1 expression increased in the control group during aging while AT2 and Mas remained unchanged PMID: 24819472
    19. Mas-mediated antioxidant effects also restored diabetic rat carotid flow, pointing to the contribution of ACE2-angiotensin-(1-7)-Mas axis in maintaining carotid flow. PMID: 24877125
    20. the inhibiting effect of RGS2 on VSMC proliferation is downregulated in vascular remodeling of injured rat aorta, and this effect is likely to be mediated by angiotensin II signaling. PMID: 24914635
    21. Mas receptor has a role in renal blood flow response to angiotensin (1-7) in male and female rats PMID: 24968411
    22. Activation of mas receptors suppressed up-regulation of pronociceptive mediators and consequently inhibited inflammatory pain. PMID: 23909597
    23. Data suggest that angiotensin-(1-7) by activating Mas recruits muscle microvasculature and enhances the metabolic action of insulin. PMID: 24711523
    24. Up-regulation of the ACE2/Ang-(1-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK/NF-kappaB pathway. PMID: 24168260
    25. elevations in the levels of thimet oligopeptidase, Ang-(1-7), and of receptor Mas transcripts are observed in chronically stimulated epileptic rats, which suggest that this axis may have a functional relevance in the pathophysiology of these animals. PMID: 24041943
    26. Activation of the ACE2/ANG-(1-7)/Mas axis attenuates stress-induced tachycardia. PMID: 23873801
    27. There is a negative feedback function between TGF-beta and ACE2, and the combined inhibition of TGF-beta and activation of the ACE2-Ang-(1-7)-Mas may be useful for treating diabetic renal fibrosis. PMID: 23174757
    28. The impact of the masR on renal haemodynamics appears to be sexually dimorphic, with greater effects in female than male rats. PMID: 22775972
    29. data indicate that Mas expression is responsive to different pathological stimuli, thereby suggesting that Mas receptor is involved in the homeostasis of the heart, as well as in the establishment and progression of cardiac diseases PMID: 22504011
    30. Data suggest that jejunal enterocyte protein and mRNA expression of Mas receptor and ACE2 are up-regulated in type 1 diabetes. PMID: 22811473
    31. Ang-(1-7) stimulates mesangial cells proliferation via Mas receptor. PMID: 22561449
    32. The Mas receptor is involved in beneficial effects of Ang-(1-7) on the phosphorylation of crucial insulin signaling mediators (Akt, GSK-3beta and AS160), in liver, skeletal muscle and adipose tissue. PMID: 22561450
    33. These results suggest organ-specific regulation of local ACE2 and Mas expression by continuous infusion of Ang-(1-7) which did not alter blood pressure of either spontaneously hypertensive rats or Wistar rats. PMID: 21436210
    34. Activation of Mas during myocardial infarction contributes to ischemia-reperfusion injury and suggest that inhibition of Mas-G(q) signaling may provide a new therapeutic strategy directed at cardioprotection. PMID: 22003054
    35. Short-term stimulation of angiotensin(1-7) receptor improves endothelial function through facilitation of nitric oxide release. PMID: 16087780
    36. The renin-angiotensin system branch formed by ACE2/Ang-(1-7)/Mas, is fully expressed in the rat ovary and regulated by gonadotropic hormones. PMID: 19703990
    37. The data presented provide the first anatomical basis for the physiological role of ANG-(1-7)/Mas axis in the modulation of different cardiovascular functions and give new insights for clarifying the role of ANG-(1-7) in the central nervous system. PMID: 17496218
    38. Our data suggest that Ang-(1-7) antithrombotic effect involves Mas-mediated NO release from platelets. We also showed that the antithrombotic effect of Ang-(1-7) in vivo is Mas dependent and that Mas is functionally important in hemostasis. PMID: 18026570

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in platelets.
  • 数据库链接：

    KEGG: rno:25153

    STRING: 10116.ENSRNOP00000020100

    UniGene: Rn.21943