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  4. Recombinant Rat Short transient receptor potential channel 1 (Trpc1)

Recombinant Rat Short transient receptor potential channel 1 (Trpc1)

  • 货号：
    CSB-CF879434RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Trpc1; Trp1; Short transient receptor potential channel 1; TrpC1; Transient receptor protein 1; TRP-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-759
  • 氨基酸序列
    MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDY YMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQKLMERIQNPEY STTMDVAPVILAAHRNNYEILTMLLKQDVALPKPHAVGCECTLCSAKNKKDSLRHSRFRL DIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFWNDYEELARQCKMFAKDLLA QARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTV WFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASY FTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEES RNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLF FMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGI FCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVV IVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYM ISSLSKWVCSHTSKGKVRRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTD QATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPKN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
  • 基因功能参考文献：
    1. transfection of TRPC1-shRNA for 48h partially inhibited Nampt-induced expression of ER stress markers and BNP in H9c2 cells. Our data suggest that TRPC1 might play an important role in cardiomyocyte hypertrophy induced by Namptinan ER stress-dependent way. PMID: 28478801
    2. the increased right ventricular systolic pressure and right ventricular hypertrophy are likely related to enhanced SOCE and upregulated TRPC1 and TRPC6 expression levels in the distal pulmonary artery. PMID: 26155749
    3. Orai1 and TRPC1, which form SOCs regulated by STIM1, play a key role in the effect of ACh on GSIS, a process that may be impaired in type 2 diabetes. PMID: 26494622
    4. Our data demonstrates that endothelin-1-mediated influx of extracellular Ca(2+) activates transient receptor potential canonical channels 1 and 6 in cerebral vascular smooth muscle cells. PMID: 25939574
    5. This study demonstrated that trpc1 expression in rat auditory midbrain neurons. PMID: 25627107
    6. we concluded that BMP4 activated Smad1/5/8 pathway is BMPRII-dependent, while the BMP4 - ERK/p-P38 - TRPC - SOCE signaling axis are likely mediated through other receptor rather than BMPRII PMID: 25461595
    7. up-regulation may be involved in carotid arterial remodeling in spontaneously hypertensive rats PMID: 25649357
    8. The upregulation of TRPC1 contributes to the contractile function in the hypertrophic myocardium by increasing [Ca(2+)]i through the SACs. PMID: 24107839
    9. Suggest that chronic cigarette smoke-induced changes in vascular tone and structure in PA and the development of pulmonary hypertension might be largely due to upregulation of TRPC1 and TRPC6 expression. PMID: 24336649
    10. TRPC1 containing channels might represent focal points for co-ordination of Ca2+ and Na+ signalling in astroglia. PMID: 23764169
    11. Experimental subarachnoid hemorrhage significantly increased mRNA and protein expressions of TRPC1 in rats. PMID: 23542055
    12. Report TRPC1 expression in hippocampal neurons in response to corticosterone. PMID: 23169006
    13. STIM1 plays an important role in the regulation of intestinal epithelial cell (IEC) apoptosis by altering TRPC1 activity, and ectopic STIM1 expression sensitizes IECs to apoptosis through induction in TRPC1-mediated Ca(2+) influx. PMID: 22547346
    14. the regulation of neurite outgrowth by TRPC1 is independent of Ca(2) influx and TRPC1-promoted neurite outgrowth depends on the surface expression of TRPC1. PMID: 22201561
    15. Suppression of TRPC1 inhibits endothelial progenitor cells proliferation and migration. PMID: 21361857
    16. a novel regulatory mechanism relying on the expression of TRPC1 and the subsequent formation of heteromeric TRPC channel complexes with reduced calcium permeability, thereby fine-tuning neuronal migration. PMID: 22157757
    17. TRPC1 expression and distribution in rat hearts PMID: 22073358
    18. STIM1 physically interacts with TRPC1 in IECs and the formation of STIM1/TRPC1 complex is necessary for the activation of TRPC1 channels during restitution after wounding. PMID: 20631248
    19. Expression levels of TRPC1 and TRPC6 ion channels are reciprocally altered in aging rat aorta and age related vasospasm disorders. PMID: 20431989
    20. These findings provide new insights about a mechanistic basis for the activation of the calcineurin/NFAT pathway by 5-HT(2A) receptors and highlight the critical role of TRPC1 in the development of cardiac hypertrophy. PMID: 20005206
    21. Sildenafil may alter basal calcium in pulmomary artery smooth muscle cells suggesting a cause and effect link between increases of TRPC1 expression and development of pulmonary hypertension. PMID: 19889962
    22. These results suggest that cholesterol influences vascular reactivity to endothelin-1 by affecting the caveolar localization of TRPC1. PMID: 14551243
    23. mGluR1-evoked slow EPSC is mediated by the TRPC1 cation channel PMID: 14614461
    24. TRPC1 contributes to basic fibroblast growth factor (bFGF)/FGF receptor-1-induced Ca2+ influx, which is involved in self-renewal of embryonic rat neural stem cells. PMID: 15758179
    25. TRPC1 channels in sinus endothelial cells of the spleen might play an important role in controlling blood cell passage through phenomena including cytoskeletal reorganization, cell retraction, and disassembly of adherens junctions. PMID: 15856275
    26. These findings strongly suggest that TRPC1 functions as store-operated Ca(2+) channels and plays a critical role in intestinal epithelial restitution by regulating CCE and intracellular [Ca(2+)](cyt). PMID: 16282360
    27. results indicate that TRPC1 proteins function as Ca2+ permeable channels in intestinal epithelial cells and play a critical role in the regulation of apoptosis PMID: 16551274
    28. We found a coexpression of TRPC1 and mGluR1 receptors in dendrites of the substantia nigra dopaminergic neurons. This reinforces the concept of an involvement of TRPC1 in mGluR1-mediated excitatory inputs in rat dopamine neurons PMID: 16930403
    29. establish TRPC1 as a functionally important regulator of cardiac hypertrophy PMID: 17174323
    30. dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion PMID: 17224452
    31. TRPC1 plays an important role in controlling contractile function of MC. Mediation of Ca(2+) entry might be the underlying mechanism for the TRPC1-associated MC contraction. PMID: 17389736
    32. These findings shed new light on the constituents of the D2R signalplex, and support the involvement of D2Rs in cellular calcium signaling pathways via a novel link to TRPC channels. PMID: 18261457
    33. Induced TRPC1 expression increases protein phosphatase 2a(PP2A) activity through Ca2+ influx; increased PP2A sensitizes intestinal epithelial cells to apoptosis as a result of NF-kappaB inactivation. PMID: 18322138
    34. These data indicate that Ca2+ entry through TRPC1 channels contributes to Ca2+ signaling in astrocytes and the consequent glutamate release from these cells. PMID: 18338793
    35. Report the properties of Orai1 and IP3 receptor-operated TRPC1 channels. PMID: 18711860
    36. results suggest that decrease in TRPC1 may be compensated by upregulated TRPC6 that possibly takes part in store-operated Ca2+ entry in vascular smooth muscle cells PMID: 19386284
    37. study concludes TRPC1 and TRPC6 channels cooperate with TRPV4 channels to mediate mechanical hyperalgesia and primary afferent nociceptor sensitization, although they may have distinctive roles PMID: 19439599
    38. STIM1 together with TRPC1 plays a pivotal role as a functional regulator of cardiac hypertrophy. PMID: 19715666

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC1 sub-subfamily
  • 组织特异性：
    Expressed in brain, hippocampus, amygdala, Purkinje cells and single neurons in the cortex and striatum.
  • 数据库链接：

    KEGG: rno:89821

    STRING: 10116.ENSRNOP00000013144

    UniGene: Rn.88592