Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Rat Somatostatin receptor type 1 (Sstr1)

Recombinant Rat Somatostatin receptor type 1 (Sstr1)

  • 货号：
    CSB-CF022724RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Sstr1; Somatostatin receptor type 1; SS-1-R; SS1-R; SS1R; SRIF-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-391
  • 氨基酸序列
    MFPNGTAPSPTSSPSSSPGGCGEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAIL ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLL RHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLG VWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAIC LCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQD DATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKS RAYSVEDFQPENLESGGVFRNGTCASRISTL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled to phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
  • 基因功能参考文献：
    1. In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy decreased mRNA levels of SSTR1 on day 14 post-infection, although it increased mRNA levels of SSTR1 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model. PMID: 29522573
    2. All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. Only SSTR1 protein co-localized to a higher extent with the islet hormones studied. PMID: 25926390
    3. up-regulated SSTR1 contributed to neuronal apoptosis after intracerebral hemorrhage, which was accompanied with reduced expression of bcl-2. PMID: 25035058
    4. This study demonistrated that sstr1 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain. PMID: 24978951
    5. Most neuropeptide Y expressing receptors in the arcuate nucleus coexpress somatostatin receptor subtype 1. PMID: 15618885
    6. data suggest that higher expression of somatostatin receptor subtype 1 and 2 mRNA induced by the gsp oncogene may be a mechanism by which gsp-positive tumors show a greater response to somatostatin PMID: 16379030
    7. the sequential activation of JAK2, SHP-2, and Src conveys the molecular signaling from SSTR1 to the activation of this phosphatase that is responsible for the final biological effects of SST PMID: 17021051
    8. Sstr1 mediates a dynamic process of endocytosis, recycling, and re-endocytosis of its cognate ligand. PMID: 17170097
    9. All five SSTR are expressed in splanchnic blood vessels. Cirrhosis reduces expression of SSTR1 in portal vein. PMID: 17617126
    10. The combined activation of SSTR1 and -2 shows a partial synergism as far as antiproliferative activity. PMID: 18566118
    11. Postsynaptic localization of sst(1) receptors and synaptic connectivity in the ARC undergo pronounced remodeling in parallel with the GH rhythm. PMID: 19553459

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Brain, pituitary, islet, jejunum, stomach, heart, spleen.
  • 数据库链接：

    KEGG: rno:25033

    STRING: 10116.ENSRNOP00000067355

    UniGene: Rn.234315