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Recombinant Rat Syndecan-4 (Sdc4)

  • 中文名称：
    大鼠Sdc4重组蛋白
  • 货号：
    CSB-CF020891RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Sdc4
  • Uniprot No.：
  • 别名：
    Sdc4; Synd4; Syndecan-4; SYND4; Ryudocan core protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-202
  • 氨基酸序列
    ESIRETEVIDPQDLLEGRYFSGALPDDEDAGGLEQDSDFELSGSGDLDDTEEPRTFPEVISPLVPLDNHIPENAQPGIRVPSEPKELEENEVIPKRVPSDVGDDDVSNKVSMSSTSQGSNIFERTEVLAALIVGGVVGILFAVFLILLLVYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
  • 基因功能参考文献：
    1. syntenin-1 negatively regulates syndecan-4 function via oligomerization and/or syndecan-4 interaction, impacting cytoskeletal organization and cell migration. PMID: 27830760
    2. syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc PMID: 26272378
    3. This study provided evidence for the differential regulation by MAPK and NF-kappaB pathways in the over-expression of syndecan-4 promoted by TNF-alpha in NP cells PMID: 25491150
    4. Locally generated Sdc4 may play a role in regulating TRPC6 channels, and may contribute to glomerular pathology. PMID: 26193076
    5. Syndecan-2 and -4 form heterdimer and this interaction regulates syndecan-mediated cellular functions. PMID: 25979339
    6. SDC4 participates in amelogenesis, and FGF10 may modulate dental epithelial cell behaviors through the regulation of SDC4 expression. PMID: 25174688
    7. in healthy discs, SDC4, through its heparan sulfate side chains, contributes to maintenance of the hypoxic tissue niche by controlling baseline expression of Sox9. PMID: 24558194
    8. data suggest that the transmembrane domain plays a major role in regulating syndecan-4 functions, and show that a domain hierarchy exists in the regulation of syndecan-4 PMID: 22504297
    9. Expression of the proteoglycan syndecan-4 and the mechanism by which it mediates stress fiber formation in folliculostellate cells in the rat anterior pituitary gland. PMID: 22645300
    10. results support liposomal delivery of syndecan-4 as an effective means to improving the potential of using growth factors to achieve therapeutic neovascularization of ischemic tissue PMID: 22307630
    11. Pravastatin can inhibit the proliferation and syndean-4 protein expression in rat vascular smooth muscle cells induced by TNF-alpha in vitro. PMID: 20501378
    12. Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles. PMID: 21518435
    13. Clustering induces redistribution of syndecan-4 core protein into raft membrane domains PMID: 11889131
    14. Syndecan-4 mRNA expression is not regulated by the FSH/cAMP/calcium pathway. PMID: 12135485
    15. Syn-4 is localized to a cytoskeletal adhesion complex unique to striated muscle, the costamere. Soon after redifferentiation of myofibrils in cultured neonatal cardiomyocytes, syn-4 is present only in costameres, not in focal adhesions. PMID: 12209563
    16. SDC4 regulates inositol phospholipid binding and signaling PMID: 12377772
    17. the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner PMID: 12493766
    18. Syndecan-4 can promote cell spreading in a beta(1) integrin-dependent fashion through PKCalpha and RhoA PMID: 12509413
    19. syndecan-4 binds PKC alpha and localizes it to focal adhesions, whose assembly may be regulated by the kinase PMID: 12571249
    20. FGF2 endocytosis requires syndecan-4 clustering-dependent activation of Rac1 and the intact CDC42-dependent macropinocytic pathway PMID: 15226395
    21. phosphorylation (Ser183) of syndecan-4 can play a critical role as a molecular switch to regulate its functions through conformational change PMID: 16310216
    22. Syndecan-4 signals to RhoA in a PKCalpha-dependent manner. PMID: 16787950
    23. mitogen-triggered syndecan-4 expression is an intrinsic part of the pathways subtending osteoblast proliferation and mineralization PMID: 16924669
    24. Syndecan-4 cytoplasmic domain forms a dimer stabilized by ionic interactions between peptides at physiological pH, a tendency which may be important for its role in regulating protein kinase C activity during focal adhesion formation. PMID: 11456484

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Secreted.
  • 蛋白家族：
    Syndecan proteoglycan family
  • 数据库链接：

    KEGG: rno:24771

    STRING: 10116.ENSRNOP00000019386

    UniGene: Rn.2029