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  4. Recombinant Rat Tumor necrosis factor ligand superfamily member 6 (Faslg)

Recombinant Rat Tumor necrosis factor ligand superfamily member 6 (Faslg)

  • 货号：
    CSB-CF008434RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Faslg; Apt1Lg1; Cd95l; Fasl; Tnfsf6; Tumor necrosis factor ligand superfamily member 6; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD antigen CD178
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-278
  • 氨基酸序列
    MQQPVNYPCPQIYWVDSSATSPWAPPGSVFSCPSSGPRGPGQRRPPPPPPPPSPLPPPSQPPPLPPLSPLKKKDNIELWLPVIFFMVLVALVGMGLGMYQLFHLQKELAELREFTNHSLRVSSFEKQIANPSTPSETKKPRSVAHLTGNPRSRSIPLEWEDTYGTALISGVKYKKGGLVINEAGLYFVYSKVYFRGQSCNSQPLSHKVYMRNFKYPGDLVLMEEKKLNYCTTGQIWAHSSYLGAVFNLTVADHLYVNISQLSLINFEESKTFFGLYKL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.; Cytoplasmic form induces gene transcription inhibition.
  • 基因功能参考文献：
    1. MiR-411 mimic inhibited oxygen-glucose deprivation - induced PC12cell apoptosis, possibly via directly targeting FasL. PMID: 29738767
    2. The expression of apoptosis-related genes Fas and FasL in rats with an experimentally induced left-side varicocele was significantly increased compared to that in the control group. PMID: 28722192
    3. Hepatitis B virus X protein modulates apoptosis in tubule renal cells and activates Fas/FasL through the MLK3-MKK7-JNK3 signaling pathway. PMID: 27606894
    4. PEDF inhibits angiogenesis in the heart by inducing tip cells apoptosis via up-regulating PPARG to increase surface FasL. PMID: 26519036
    5. Up-regulated FasL pathways mediating differentiation. PMID: 25428397
    6. These results indicate that chorionic gonadotropin promotes follicular development via downregulation of death-inducer Fas/FasL expression and promotion of ovarian cell proliferation. PMID: 25294749
    7. Sulforafan inhibited galactosamine/lipopolysaccharide induced caspase-3 activation and suppressed FAS and FASL expression. PMID: 25439027
    8. CCN1, often co-expressed with FasL in a stressed heart, sensitizes cardiomyoblasts to FasL-induced apoptosis. PMID: 24631528
    9. pTREFasLcHS4V16 with an improved tet-on system can precisely regulate the expression of FasL gene and apoptosis for arthritis treatment. PMID: 21792649
    10. Results of the study indicate a time-dependent increase in the mRNA levels of Fas Ligand (FasL) and phosphatase and tensin homologue deleted on chromosome 10 (PTEN)up until 6 h after death. PMID: 24297385
    11. This study showed increase in the C-fibre response and an upregulation of the gene expression of Fasl 180 minutes after application of NP onto the nerve roots PMID: 23711477
    12. Cerebral ischemia/reperfusion mediates procaspase-3 denitrosylation and activation through GluR6-FasL-Trx2 pathway, which leads to neuronal apoptosis and cell death. PMID: 23949220
    13. The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis. PMID: 23940767
    14. Prolonged mechanical ventilation induces apoptosis of alveolar type II cells in newborn rats via the extrinsic death pathway and the FasL/Fas system. PMID: 23934924
    15. Overexpression of SIRT1 up-regulates FasL expression in both flow-restricted mouse carotid arteries and serum-stimulated vascular smooth muscle cell. PMID: 23806367
    16. Hypoxia causes the upregulation of FasL expression but the downregulation of miR-21 expression in microglia. PMID: 22907769
    17. Soluble FasL is locally produced in the chronically inflamed testis. PMID: 22892327
    18. FasL governs the immunoregulatory property of dental pulp stem cells in the context of inducing T-cell apoptosis. PMID: 22904205
    19. In summary, the Fas/FasL pathway involved in alveolar epithelial cell apoptosis could be important in the pathogenesis of seawater-induced acute lung injury PMID: 22609371
    20. Carbon disulfide causes apoptosis of sertoli cells and increases expression of FasL. PMID: 17241545
    21. Data suggest the potential therapeutic applications for suppression of rheumatoid arthritis (RA) by local joint delivery of CTLA4-FasL. PMID: 22354915
    22. Endothelial cells with expression of FasL or viruses recombinant with FasL gene transfusion can preserve liver function and prolong the survival time of liver allografts. PMID: 22664023
    23. observations indicate that CTLA4-FasL protein represents a significantly suppressive effect on inflammatory fibroblast-like synoviocytes' proliferation PMID: 22325471
    24. Fluorofenidone significantly reduced Ang II-induced increases in Fas, FasL at the mRNA level. PMID: 21586345
    25. analysis of of functionally active Fas ligand interfering protein (FIP) PMID: 18204739
    26. Apoptosis mediated by Fas/FasL may play an important role in the pathogenesis of acute liver injury. PMID: 16831245
    27. overexpression of miR-21 protects against ischemic neuronal death, and that downregulation of FASLG, an important cell death-inducing ligand whose gene is targeted by miR-21, probably mediates the neuroprotective effect PMID: 20840605
    28. The reverse transcriptase polymerase chain reaction demonstrated Fas gene expression in liver and renal tissues at 1 hour after liver transplantation. PMID: 20620473
    29. Se deficiency can lead to over expression of Fas/FasL. PMID: 19239001
    30. p,p'-DDE could induce DNA damage and FasL gene expression of Sertoli cells of rat testis. PMID: 16921742
    31. down-regulating FasL expression and/or function in glial malignancies can enhance T-cell tumor infiltration and inhibit tumor growth PMID: 20406899
    32. Resveratrol treatment significantly increased the apoptotic indices of pancreatic acinar cells and the levels of FasL mRNA and protein in rats with severe acute pancreatitis. PMID: 19304523
    33. Fas/FasL system may function as a possible mechanism mediating estrogen-induced apoptosis in the thymus. The present data demonstrate...Fas/FasL system could play an important role maintaining this balance as the mediators of programmed cell death. PMID: 11642679
    34. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase PMID: 11790788
    35. Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis PMID: 11925448
    36. Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism. PMID: 11981771
    37. Oxidative stress is a major stimulus in eliciting Fas and FasL expression in NGF-differentiated PC12 cells. Moreover, we describe here for the first time the existence of cAMP-dependent mechanism(s) modulating Fas and FasL expression. PMID: 12111799
    38. findings support the hypothesis that the expression of FasL in normal ovary is hormonally sensitive PMID: 12113885
    39. Hyperosmotic hepatocyte shrinkage induces CD95 trafficking to the plasma membrane, which involves JNK-, PKA-, and PKC-dependent mechanisms and sensitizes hepatocytes toward CD95L-mediated apoptosis. PMID: 12198652
    40. The consequences of FasL overexpression depend on the subcellular compartment and species in which FasL enforced expression is targeted and this is at least partially related to FLIP levels PMID: 12477972
    41. The results suggest that recruitment of preformed FasL from intracellular compartments, rather than its biosynthesis, is responsible for the increase in FasL on the cell surface following IFN-gamma stimulation. PMID: 12904679
    42. downregulation of Akt signalling and activation of Forkhead is a prerequisite for the induction of FasL promoter PMID: 14576824
    43. CD95 ligand-induced CD95 activation in rat hepatocytes is inhibited by CD95-tyrosine nitration PMID: 14679192
    44. FasL expression in rat testis is present from the early postnatal days up to the adult, and the Sertoli cells is the main FasL expressing cell within the seminiferous tubule. PMID: 15379972
    45. Fas ligand is not detected in the notochord. During intervertebral disc formation, Fas ligand is expressed in the nucleus pulposus. The disc's immune privilege may begin early in disc formation. Fas ligand may play an important role in disc formation. PMID: 15507796
    46. NO inhibited Fas/FasL system-induced apoptosis by suppressing activation of the caspases, pointing to a cross-talk between Fas/FasL system-induced apoptosis pathway and NO-mediated antiapoptotic pathway in ovarian follicle atresia. PMID: 15528299
    47. FasL protein expression was localized to caveolae membrane domains PMID: 15541714
    48. Acute pancreatitis induces liver injury and hepatocyte death while up-regulating FasL, p38-MAPK, and caspase-3. Fas is up-regulated within Kupffer cells, suggesting that FasL may autoregulate its production by inducing its originator-cell death. PMID: 15555619
    49. METH causes some of its neurodegenerative effects, in part, via stimulation of the Fas-mediated cell death pathway consequent to FasL up-regulation mediated by activation of multiple TFs. PMID: 15644446
    50. Mitochondria-derived ROS and calcium play a key role in stimulating DOX-induced 'intrinsic and extrinsic forms' of apoptosis in cardiac cells with Fas L expression via the NFAT signalling mechanism. PMID: 15799720

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen.; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted.; [FasL intracellular domain]: Nucleus.
  • 蛋白家族：
    Tumor necrosis factor family
  • 组织特异性：
    Expressed in activated splenocytes and thymocytes. Moderate or weak expression found in small intestines, kidney and lung.
  • 数据库链接：

    KEGG: rno:25385

    STRING: 10116.ENSRNOP00000003998

    UniGene: Rn.9725