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  4. Recombinant Rat Tumor necrosis factor receptor superfamily member 16 (Ngfr)

Recombinant Rat Tumor necrosis factor receptor superfamily member 16 (Ngfr)

  • 货号：
    CSB-CF015780RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ngfr; Tnfrsf16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-425
  • 氨基酸序列
    KETCSTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDNVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCAYGYYQDEETGHCEACSVCEVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWIPRSTPPEGSDSTAPSTQEPEVPPEQDLVPSTVADMVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKGDGNLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGAQDSATLDALLAALRRIQRADIVESLCSESTATSPV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. In response to proNGF binding, the heterodimeric receptor with SORCS2 activates a signaling cascade that leads to decreased Rac activity, reorganization of the actin cytoskeleton and neuronal growth cone collapse. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
  • 基因功能参考文献：
    1. p75NTR is sufficient to mediate the modulation of myogenic cells differentiation by NGF in terms of structural, metabolic and functional changes. PMID: 29202822
    2. Data indicate that p75 neurotrophin receptor (p75NTR) is an important mediator of irradiation-induced cognitive deficits by regulating dendritic development and synapse structure. PMID: 28380447
    3. alleviated the osteogenic differentiation of ectomesenchymal stem cells (EMSCs), and LNGFR enhanced the osteogenic differentiation of EMSCs by decreasing SOST PMID: 29226516
    4. Co-immunoprecipitation and biochemical fractionation data suggested that p75 TM stimulates TrkB phosphorylation at the cell membrane. PMID: 28821608
    5. p75(NTR) and NIX may play critical roles in intracerebral hemorrhage-induced neuronal apoptosis in vitro and in vivo. PMID: 27726026
    6. Basal forebrain p75NTR regulates hippocampal choline acetyltransferase activity. PMID: 26864466
    7. P75 positive ectomesenchymal stem cells showed more odonto-differentiation potential than P75 negative ectomesenchymal stem cells both in vivo and in vitro. PMID: 27038014
    8. that p75NTR still may be a potential and novel target for therapeutic intervention for spinal cord injury PMID: 25394381
    9. glycation of TrkA reduced the affinity to NGF by a factor of three, which could be shown to lead to a reduction of NGF-dependent neurite outgrowth in PC12 cells. PMID: 26212415
    10. Study of the spatial structure and mobility of the transmembrane and intracellular parts of p75NTR, incorporated into lipid-protein nanodiscs of various sizes and compositions, by solution NMR spectroscopy PMID: 26287629
    11. This study suggested that alterations of p75 neurotrophin receptor and Myelin transcription factor 1 in the hippocampus of perinatal phencyclidine treated rats PMID: 26071990
    12. these studies suggested that modulation of p75NTR under hypoxic condition could enhance C6 cells migration and invasion by induction of EMT, and activation of the FAK pathway PMID: 25527128
    13. Taken together, N-SMase activation played a pivotal role in CAPE-induced apoptosis by activation of the p38 MAPK pathway and NGF/p75NTR may explain a new role of CAPE induced apoptosis in C6 glioma. PMID: 24997497
    14. The expression of BDNF and of its TRKB and p75NT receptors correlates with the proliferation rate of biliary tree during bile duct ligation. PMID: 25665281
    15. Activation of the p75NTR signaling cascade mediates mechanical hyperalgesia. PMID: 24095693
    16. Isoflurane but not sevoflurane or desflurane postexposure aggravates neurotoxicity in preinjured neurons via activation of p75 and NF-kappaB. PMID: 25329094
    17. data suggest a novel mechanism linking oxidative stress to ligand-independent cleavage of p75(NTR), resulting in axonal fragmentation and neuronal death PMID: 24939843
    18. Exposure to Abeta increased surface expression of p75 neurotrophin receptor, and the increase was abolished in the presence of gamma-Eno peptide. PMID: 23842744
    19. In this process a pivotal role is performed by the p75 receptor PMID: 23973667
    20. The pathway of NGF-TrkA expressed in the small-size neurons, associated with neuropathic pain, was shifted to the NGF-p75 pathway expressed in the large-size neurons after RTX treatment, in association with neuropathic pain inhibition. PMID: 23615109
    21. analysis of the structure and self-association of the death domain of p75(NTR) PMID: 23472109
    22. LMPs markedly inhibit choroidal angiogenesis via mechanisms that are dependent on the integrity of the RPE, and that are mediated largely by the PEDF and proapoptotic activities of p75NTR. PMID: 23920372
    23. Results suggest that p75NTR contributes to neuropathic pain associated with brachial plexus avulsion (BPA), and that inhibition of p75NTR reduces neuropathic pain. PMID: 23324933
    24. This study shows that alteration in p75NTR, Trk A, and caspase-9 expression starts as early as 6 hours after spinal cord injury PMID: 23809594
    25. Dissociation of c-Jun kinase (JNK) and caspase-3 activities indicated that JNK is necessary but not sufficient for p75(NTR)-mediated cell death. PMID: 23260665
    26. p75NTR may not play a main role in Abeta internalization at the concentrations tested but is responsible for Abeta induced toxicity in primary neurons PMID: 22183269
    27. The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by gamma-secretase PMID: 23105112
    28. The ER retained intrabody SH325-G7-KDEL not only induces phenotypic knockdown of this p75NTR but also p75NTR-associated cellular responses in PC12 cells. PMID: 22292018
    29. NGF receptors are localized in the mitochondrial compartment of undifferentiated human podocytes and in all tissues analyzed including rat central nervous system. PMID: 22138126
    30. Increased extracellular nerve growth factor precursor levels following seizures are stabilized by altered MMP-7 enzymatic activity, leading to increased neuronal death via activation of p75(NTR). PMID: 22238106
    31. These results suggest that p75(NTR) contributes to spiral ganglion Schwann cell responses to deafening and neural degeneration. PMID: 21658451
    32. Results indicate that p75(NTR) is involved in both acetylcholine release and axonal retraction during postnatal axonal competition and synapse elimination. PMID: 21674565
    33. The presence analysis reveals the new localization of p75NTR in the choroid plexus and, the distribution mainly in the cytoplasm and cerebrospinal fluid (CSF) side of the epithelial cells. PMID: 21569322
    34. p75-siRNA downregulated both p75(NTR) and Rho-A at RNA level in rat Schwann cells and decreased cell apoptosis. PMID: 21358016
    35. These studies identify a novel signaling circuit in which Trk activates ADAM17-dependent p75NTR production to feedback to sustain Trk signaling and Trk-dependent survival. PMID: 21411748
    36. Immobilised DHEA pulls down TrkA and p75NTR receptors, and induces TrkA- and p75NTR-mediated signaling. PMID: 21541365
    37. Data suggest that the effects of necdin deletion on the developing nervous system may depend on the relative expression of p75NTR and TrkA in the cells of particular regions of the nervous system. PMID: 21150695
    38. Results describe the presence of GABAergic neurons which express p75 in the basal forebrain. PMID: 21238591
    39. These data suggest that 4-methylcatechol might exert its antiapoptotic actions through NGF/TrkA system which may block NGF/p75(NTR) activation in pancreatic beta cells of hyperglycemic rats. PMID: 21295348
    40. Results suggest involvement of the p75(NTR) signaling pathway in the long-lasting decremental form of synaptic plasticity. PMID: 20890994
    41. LINGO-1 inhibits multiple aspects of oligodendrocyte differentiation independently of the LRRs via a process that requires p75(NTR) signalling PMID: 20659559
    42. Expressions of TrkB, TrkC and p75 were elevated in spiral ganglion cells during cisplatin-induced ototoxicity. PMID: 19141250
    43. TrkA activity is neuroprotective, while p75NTR activity is neurotoxic through a paracrine mechanism in retinal neurodegeneration PMID: 20943663
    44. Data suggest that generation of the soluble p75NTR intracellular domain by Trk-induced cleavage plays a fundamental role in Trk-dependent signaling events. PMID: 20530577
    45. Macrophages in vivo (ED1+) and isolated in vitro (CD11b+) express moderate levels of proBDNF, sortilin and p75NTR after spinal cord injry. PMID: 20083190
    46. Data show that unique neurotrophin receptor tumor profiles may determine tumor aggressiveness and chemoresistance. PMID: 19701634
    47. NGF administration reverses the neuro-glial morphomolecular changes occurring in neuropathic animals paralleled by alterations in neurotrophin receptors ratio. PMID: 19585233
    48. explored the binding characteristics of proNGF to sortilin using surface plasmon resonance and cell-based assays and determined that calcium ions promote the formation of a stable ternary complex of proNGF-sortilin-p75NTR PMID: 20036257
    49. the p75 ICD generated by gamma-secretase cleavage is capable of modulating transcriptional events in the nucleus. PMID: 20022966
    50. The key mutations along the NGF receptor interface are transmitted inside the cell to enable the generation of survival-selective recombinant NGF muteins that may represent novel pharmacologic lead agents for the amelioration of Alzheimer disease. PMID: 19762468

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Cell projection, dendritic spine.
  • 数据库链接：

    KEGG: rno:24596

    STRING: 10116.ENSRNOP00000007268

    UniGene: Rn.10980