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  4. Recombinant Xenopus laevis Apelin receptor B (aplnr-b)

Recombinant Xenopus laevis Apelin receptor B (aplnr-b)

  • 中文名称：
    Recombinant Xenopus laevis Apelin receptor B(aplnr-b)
  • 货号：
    CSB-CF650342XBE
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    aplnr-b
  • Uniprot No.：
  • 别名：
    aplnr-b; agtrl1-b; agtrl1b; Apelin receptor B; Angiotensin receptor-like 1b; Angiotensin receptor-related protein B; G-protein coupled receptor APJ-B; APJb
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-363
  • 氨基酸序列
    MESEGFSATTEQYEYYDYANETGLQPCDETDWDFSYSLLPVFYMIVFVLGLSGNGVVIFT VWKAKPKRRSADTYIGNLALADLAFVVTLPLWATYTALGFHWPFGSALCKLSSYLVLLNM FASVFCLTCLSFDRYLAIVHSLSSAKLRSRSSILVSLAVIWLFSGLLALPSLILRDTRVE GNNTICDLDFSGVSSKENENFWIGGLSILTTVPGFLLPLLLMTIFYCFIGGKVTMHFQNL KKEEQKKKRLLKIIITLVVVFAICWLPFHILKTIHFLDLMGFLELSCSAQNIIVSLHPYA TCLAYVNSCLNPFLYAFFDLRFRSQCFFFFGFKKVLQGHLSNTSSSLSAQTQKSEIHSLA TKV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Promotes angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. May promote sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone. Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure. Acts upstream of the i/o type of G-alpha proteins in the differentiation of endothelium, erythroid cells, myeloid cells and cardiomyocytes.
  • 基因功能参考文献：
    1. study reports that signaling by apelin and its G protein-coupled receptor APJ is essential for embryonic angiogenesis PMID: 17412318
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in all blood vessels including the posterior cardinal vein, intersomitic veins and the vitelline vein network.
  • 数据库链接：

    KEGG: xla:379537

    UniGene: Xl.34