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中文名称:人巨噬细胞炎性蛋白1α(MIP-1α/CCL3)酶联免疫试剂盒
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货号:CSB-E04662h
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规格:96T/48T
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价格:¥3200/¥2500
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其他:
产品详情
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产品描述:
The product CSB-E04662h is a sandwich ELISA kit developed to measure concentrations of human macrophage inflammatory protein-1α (MIP-1α) in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of MIP-1α in samples. The color intensity is measured at 450 nm via a microplate reader.
MIP-1α, also called CCL3, is a pro-inflammatory chemokine expressed constitutively in the bone marrow, including by osteoblasts. It is induced during inflammation. CCL3 is a chemotactic cytokine crucial for inflammatory cell recruitment in homeostatic and pathological conditions. In addition to its proinflammatory activities, CCL3 negatively regulates the proliferation of hematopoietic stem/progenitor cells (HSPCs) in the bone marrow (BM). CCL3 and its receptor CCR1 are reported to mediate the bone remodeling that occurs during orthodontic tooth movement, and may also regulate osteoclastogenesis in osteomyelitis. CCL3 might stimulate cancer progression by promoting leukocyte accumulation, angiogenesis, and tumor growth.
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别名:C C motif chemokine 3 ELISA Kit; CCL 3 ELISA Kit; CCL3 ELISA Kit; CCL3_HUMAN ELISA Kit; Chemokine (C C motif) ligand 3 ELISA Kit; Chemokine C C motif ligand 3 ELISA Kit; Chemokine ligand 3 ELISA Kit; G0/G1 switch regulatory protein 19 1 ELISA Kit; G0/G1 switch regulatory protein 19-1 ELISA Kit; G0S19 1 ELISA Kit; G0S19 1 protein ELISA Kit; Heparin binding chemotaxis protein ELISA Kit; L2G25B ELISA Kit; LD78 alpha ELISA Kit; LD78-alpha(4-69) ELISA Kit; LD78alpha ELISA Kit; Macrophage inflammatory protein 1 alpha ELISA Kit; Macrophage inflammatory protein 1-alpha ELISA Kit; macrophage inflammatory protein 1a ELISA Kit; MIP 1 alpha ELISA Kit; MIP 1A ELISA Kit; MIP-1-alpha ELISA Kit; MIP-1-alpha(4-69) ELISA Kit; MIP1 alpha ELISA Kit; MIP1A ELISA Kit; PAT 464.1 ELISA Kit; SCYA 3 ELISA Kit; SCYA3 ELISA Kit; SIS alpha ELISA Kit; SIS beta ELISA Kit; SIS-beta ELISA Kit; Small inducible cytokine A3 ELISA Kit; small inducible cytokine A3 (homologous to mouse Mip-1a) ELISA Kit; Small-inducible cytokine A3 ELISA Kit; Tonsillar lymphocyte LD78 alpha protein ELISA Kit
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缩写:
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Uniprot No.:
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种属:Homo sapiens (Human)
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样本类型:serum, plasma, tissue homogenates
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检测范围:39 pg/ml - 2500 pg/ml
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灵敏度:9.75 pg/ml
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Immunology
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测定原理:quantitative
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测定方法:Sandwich
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数据处理:
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货期:3-5 working days
引用文献
- Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3 YF Wei,Cell communication and signaling,2024
- The prognostic role of chemokine ligand-3 in chronic lymphocytic leukemia Fetnat M Tolbah.et al,/,2016
相关产品
靶点详情
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功能:Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
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基因功能参考文献:
- Tumor levels of CCL2 (mean +/- standard deviation = 530.1 +/- 613.9 pg/mg), CCL3 (102.7 +/- 106.0 pg/mg), and CCL4 (64.98 +/- 48.09 pg/mg) were higher than those found in healthy tissue PMID: 30419802
- During early remission from methamphetamine (MA), model mice exhibited increased anxiety-like behavior and reduced expression of chemokine (C-C motif) ligand 3 (ccl3) in the hippocampus relative to saline-treated mice. Human adults actively dependent on MA and those in early remission had elevated symptoms of anxiety as well as reductions in plasma levels of CCL3, relative to adults with no history of MA abuse. PMID: 29402784
- As depression became more severe the serum levels of MIP-1alpha increased. PMID: 29339257
- results suggested that genetic variants at the CCL3 and CCL4 loci may be marker SNPs for risk of HCV treatment outcome. PMID: 29705123
- Telomere length and mRNA expressions of IL6 and MIP1alpha were significantly longer or higher in bone marrow mesenchymal stem cells of multiple myeloma than those of controls. PMID: 28677723
- The CCL3 and CCL4 chemokines might not be involved in differential susceptibility to the digestive and cardiac clinical forms of chronic Chagas disease, and it seems they do not influence the development of LVSD. PMID: 28002786
- The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. PMID: 26898119
- the DR3/TL1A pathway directly enhances human OC formation and resorptive activity, controlling expression and activation of CCL3 and MMP-9. PMID: 28062298
- serum levels of MIP-1alpha could predict survival outcomes in patients with ENKTL. PMID: 26928433
- elevated CCL3 in the leukemic environment suppresses erythropoiesis via CCR1-p38 activation PMID: 27109512
- analysis of sudden infant death syndrome brains shows downregulation of MyD88 in tissue from SIDS brains, as well as the downregulation of the genes encoding CCL3 and UNC13 in the liver PMID: 26959483
- we demonstrate an association of CCL3 expression by CLL cells with increased numbers of CD3+ T cells and CD57+ cells in the lymph node microenvironment, which may promote CLL cell survival and proliferation. PMID: 26458057
- The N termini of CC chemokines are shown to be involved in receptor binding and oligomerization. We also report an alternative CCL3 oligomer structure that reveals how conformational changes in CCL3 N termini profoundly alter its surface properties and dimer-dimer interactions to affect GAG binding and oligomerization. Such complexity in oligomerization and GAG binding enables intricate, physiologically relevant regulatio PMID: 27091995
- CCL3 promotes VEGF-A expression and angiogenesis in human osteosarcoma cells by down-regulating miR-374b expression via JNK, ERK, and p38 signaling pathways. PMID: 26713602
- The residues on the N-loop and beta-sheets of MIP-1a are close to both CCR1 and CCR5, and those in the C-terminal helix region are close to CCR5. PMID: 26472202
- An increased MIP-1alpha level in nasopharyngeal aspirates from patients with acute respiratory symptoms during the first wheezing episode caused by viral infections might predict recurrent wheezing. PMID: 26494023
- Tregs from subjects with established type 1 diabetes were impaired in their ability to produce CCL3 and CCL4. PMID: 26854929
- Pleural and serum MIP1a were lower in patients with lung cancer compared to lung metastasis, pneumonia, tuberculosis, and transudate pleural effusion. PMID: 26620310
- AEG-1 mediates CCL3/CCR5-induced EMT development via both Erk1/2 and Akt signaling pathway in CM patients, which indicates CCL3/CCR5-AEG-1-EMT pathway could be suggested as a useful target to affect the progression of CM. PMID: 26134542
- The EP in TKA differed from EP in aseptically failed THA by lower CCL3 and DC-STAMP mRNA and protein expression. EP of all studied inflammatory and osteoclastogenic molecules were similar in knee and hip OA. PMID: 25151085
- A significantly higher percentage of healthy asymptomatic persons possibly exposed to asbestos had detectable levels of serum CCL3 compared to healthy unexposed control subjects. PMID: 25940505
- APOE varepsilon4 genotype specifically modulates astrocyte secretion of potent microglial chemotactic agents, including CCL3 PMID: 25092803
- Macrophage inflammatory protein-1alpha shows predictive value as a risk marker for subjects and sites vulnerable to bone loss in a longitudinal model of aggressive periodontitis. PMID: 24901458
- In COPD patients, CCL3 is upregulated in sputum and may facilitate recruitment of macrophages into airways. PMID: 25183374
- Serum/urinary MIP-1a responds to infection but cannot be used as reliable biomarker in childhood urinary tract infections. PMID: 25618120
- Sequence variants in the CCL3 chemokine gene family in the HapMap West African reference population have been identified. PMID: 24952210
- MIP-1alpha levels in Jurkat cells appeared to be an important factor for its transendothelial migration PMID: 25245399
- se results indicate that CCL2 and CCL3 are associated with progression of oral squamous cell carcinoma PMID: 25060177
- Our results confirm the strong influence of previous immunity in subsequent dengue infections, and confer a possible pathogenic role to CCR1 and CCL3 in dengue disease and a possible protective role for CCL5, probably through CCR5 interaction. PMID: 24157267
- The detection of basal level of IgM rheumatoid factor, IgM and also certain cytokines can be useful in prognosis of effectiveness of rituximab therapy under rheumatoid arthritis. PMID: 25080789
- Gene expression profiling in bone marrow from multiple myeloma patients with and without osteolysis vs controls with other hematologic neoplasms showed only weak CCL3 expression. PMID: 24556596
- MIP-1alpha is a predominant factor responsible for the enhancement of bone resorption and increased angiogenesis PMID: 24277416
- Greater adiposity is associated with higher MIP-1alpha and lower soluble CD14 levels, possibly reflecting an important role for cells of the monocyte/macrophage lineage. PMID: 23748193
- Transcription of CCL3 and CCL4 by THP-1 monocytic cells up-regulated in the presence of 27-Hydroxycholesterol and 7alpha-hydroxycholesterol. PMID: 24370436
- the role of Tax2-mediated activation of the nuclear factor kappa B (NF-kappaB) signalling pathway on the production of the anti-viral CC-chemokines MIP-1alpha, MIP-1beta and RANTES. PMID: 24116893
- Data indicate that VIP and PACAP increased macrophage resistance to HIV-1 replication by inducing the synthesis of beta-chemokines CCL3 and CCL5 and IL-10 following preferential activation of the receptors VPAC2 and PAC1. PMID: 23818986
- JAK2 and STAT3 activation is not essential for CCL3, CCL5 or CCL8 induced chemotaxis. PMID: 22987449
- Epstein-Barr virus latent membrane protein 1 (LMP1)-mediated Jun N-terminal protein kinase activation was responsible for upregulation of CCL3 and CCL4 in B cells. PMID: 23760235
- either the CCL3 gene may play a significant role in CCL3 production and/or that as yet undefined mechanisms regulate production of CCL3 from variable CCL3L copy number. PMID: 23295355
- High serum CCL-3 is associated with disease severity of generalized pustular psoriasis. PMID: 23334651
- These findings suggest that MIP-1alpha and IL-17 may play important roles in acute exacerbation of asthma induced by RSV in an animal model. PMID: 23711864
- This study examined the role of three African CCL3 haplotypes in HIV-1 infant susceptibility, maternal HIV-1 transmissibility and HIV-1 disease progression in the mothers. PMID: 23151487
- These findings suggest that the increased expression of CCL3, CCR1, and CCR5 may influence the immune response in RAS by T(H)1 cytokine polarization. PMID: 22727097
- Our findings indicate that TNFalpha and IL-1beta modulate the expression of CCL3 in nucleus pulposis cells by controlling the activation of MAPK, NF-kappaB, and C/EBPbeta signaling. PMID: 23233369
- Our results suggest vital roles for CCL3-mTORC2-isoform PKB/Akt1 S473 phosphorylation axis in FOXP3+Treg cells and the development of psoriasis. PMID: 23223135
- Serum CCL3, CCL5 and CCL18 are independently associated with the risk of short-term mortality in acute coronary syndrome patients. PMID: 23029252
- Tumor-infiltrating monocytic myeloid-derived suppressor cells produce high levels of transgenic CCR5 ligands CCL3, CCL4, and CCL5 and directly attract regulatory T cells (Tregs) in a CCR5-dependent manner. PMID: 23152559
- MIP-1alpha was found to correlate with WHO grade among invasive gliomas, and MIP-1alpha promoted human glioblastoma cell proliferation and migration. PMID: 22307528
- The mRNA expression of MIP-1alpha was markedly higher in chronic nonbacterial prostatitis/chronic pelvic pain syndrome patients than in controls. PMID: 22295852
- Data indicate that IFN2b treatment upregulates the expression of CCR5, RANTES, MIP-1alpha and MIP-1beta on monocytes/macrophages. PMID: 22085486
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亚细胞定位:Secreted.
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蛋白家族:Intercrine beta (chemokine CC) family
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数据库链接:
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