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ECSIT Antibody

  • 中文名称：
    ECSIT兔多克隆抗体
  • 货号：
    CSB-PA859414ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial antibody at 10μg/ml + Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 50, 34, 25 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA859414ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA859414ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ECSIT Polyclonal antibody
  • Uniprot No.：
    Q9BQ95
  • 基因名：
  • 别名：
    Ecsit antibody; ECSIT homolog antibody; ECSIT protein antibody; ECSIT_HUMAN antibody; Evolutionarily conserved signaling intermediate in Toll pathway; mitochondrial antibody; Evolutionarily conserved signaling intermediate in Toll pathways antibody; Likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved antibody; Protein SITPEC antibody; Signaling intermediate in Toll pathway evolutionarily conserved antibody; SITPEC antibody; SITPEC protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial protein (185-431AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.; Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
  • 基因功能参考文献：
    1. mediates virus-triggered type I IFN induction by bridging RIG-I and MDA5 to the VISA complex PMID: 25228397
    2. Ubiquitination of ECSIT might have a role in the regulation of NF-kappaB activity in TLR4 signaling. PMID: 25355951
    3. s conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule and their interaction is mechanistically important in IL-1beta induction of NF-kappaB activation. PMID: 25449573
    4. Data show that the ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) complex, including MEKK7 (TAK1) and TNF receptor-associated factor 6 (TRAF6), plays a role in Toll-like receptor 4 -mediated signals to activate NF-kappa B. PMID: 25371197
    5. TRIM59 interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway. PMID: 22588174

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Mitochondrion.
  • 蛋白家族：
    ECSIT family
  • 数据库链接：

    HGNC: 29548

    OMIM: 608388

    KEGG: hsa:51295

    STRING: 9606.ENSP00000270517

    UniGene: Hs.515146