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MC1R Antibody

  • 货号：
    CSB-PA013558LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A375 whole cell lysate
      All lanes: MC1R antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35 kDa
      Observed band size: 35 kDa
    • IHC image of CSB-PA013558LA01HU diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA013558LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA013558LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品描述：

    The MC1R polyclonal antibody is produced by the immune system of a rabbit against the recombinant human MC1R protein (1-37aa). This MC1R antibody targets the human MC1R protein. Its purity is at least 95% using protein G purification. Multiple applications including ELISA, WB, IHC, and IF have been used to validate the specificity and reliability of this MC1R antibody.

    The MC1R protein mainly functions to regulate the production of the pigment melanin in melanocytes. Melanin is responsible for giving color to the skin, hair, and eyes and also helps to protect the skin from the harmful effects of UV radiation. Mutations in the MC1R gene can affect the function of MC1R protein and thus alter the generation of melanin, leading to differences in skin, hair, and eye color, as well as differences in the ability to tan and the risk of developing skin cancer.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MC1R Polyclonal antibody
  • Uniprot No.：
    Q01726
  • 基因名：
  • 别名：
    CMM5 antibody; MC1 Receptor antibody; MC1-R antibody; MC1R antibody; Melanocortin 1 receptor antibody; Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody; Melanocortin receptor 1 antibody; Melanocyte-stimulating hormone receptor antibody; Melanotropin receptor antibody; MSH-R antibody; MSHR antibody; MSHR_HUMAN antibody; SHEP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Melanocyte-stimulating hormone receptor protein (1-37AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MC1R Antibody (CSB-PA013558LA01HU)，的标记方式是Non-conjugated。对于MC1R Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013558LB01HU MC1R Antibody, HRP conjugated ELISA
    FITC CSB-PA013558LC01HU MC1R Antibody, FITC conjugated
    Biotin CSB-PA013558LD01HU MC1R Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
  • 基因功能参考文献：
    1. the association between particular MC1R alleles and the risk of skin cancers, was investigated. PMID: 29968341
    2. there is an association between TERT promoter mutations and MC1R variants in melanoma patients PMID: 27930874
    3. with regard to cutaneous malignant melanoma risk, no association found in the combination of GSTP1 Ile105Val with MC1R RHC-variant alleles [meta-analysis] PMID: 27304781
    4. In familial melanoma patients, the presence of MC1R R variants was associated with an increased prevalence of environmental risk factors and features associated with UV radiation-induced damage. PMID: 29405243
    5. In melanomas and for somatic C>T mutations, a signature linked to sun exposure, the expected single-nucleotide variant count associated with the presence of an R allele is estimated to be 42% (95% CI, 15-76%) higher than that among persons without an R allele. PMID: 27403562
    6. These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth. PMID: 29316344
    7. In both melanoma cell lines, alphaMSH determined the reduction of proliferation through the PI(4,5)P2/PLC pathway, employing PPARgamma as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma. PMID: 29020973
    8. Carriage of any MC1R variant, one variant and two or more variants, compared with not having such variants was significantly associated with fair hair color, skin type I/II, and presence of freckles. PMID: 27251790
    9. key molecular events driving MC1R-mediated enhancement of genome maintenance and MC1R-induced pigment induction in melanocytes are distinct PMID: 28094871
    10. amino acid residue 128 in Transmembrane 3 (TM3) of MC1R, or amino acid residue L133 in TM3 of the MC4R, play crucial roles in ligand des-Trp(9)-NDP-alpha-MSH selectivity at MC1R or MC4R. PMID: 28579117
    11. In a heterologous expression system, MC1R-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 and was impaired by siRNA-mediated MGRN1 knockdown thus pointing to MGRN1 as the responsible E3-ligase. PMID: 28947386
    12. POMC and MC1R were significantly lower in vitiligo lesional skin than in non-lesional skin as well as in controls and they were significantly higher in non-lesional skin than in the skin of the controls. PMID: 26437741
    13. MC1R gene could modify the age of onset in Spanish Huntington's disease patients. PMID: 27924526
    14. results highlight a central role for MC1R palmitoylation in pigmentation and protection against melanoma PMID: 28869973
    15. MC1R variant p.V92M (rs2228479) was present in 72 (14%) patients and 15 (9%) controls and confers increased risk of developing late-onset Alzheimer's disease, especially in those patients whose genetic risk could not be explained by APOE genotype. This association remains and even increased in the subset of 69 patients with typical AD cerebrospinal fluid profile. No association was found between p.V92M and age of onset. PMID: 28059796
    16. MC1RR163Q is associated with a lower risk of complicated sepsis after trauma. Therapeutic targeting of MC1R may be beneficial for trauma patients at risk for complicated sepsis PMID: 27488084
    17. This study evaluated the association of perceived facial age with multiple single nucleotide polymorphisms in the MC1R gene. PMID: 27133870
    18. MC1R-positive basophils are present exclusively in the nasal mucosa of those AR patients who had undergone nasal allergen provocation 24 h before. PMID: 27196703
    19. MC1R genotype is associated with patient phenotypes with BRAF and NRAS mutations in melanoma PMID: 28842324
    20. MC1R mutation is associated with Melanoma. PMID: 28024115
    21. Melanocortin-1 receptor variants are associated with high melanoma risk. PMID: 27540956
    22. It was suggested to be involved in Parkinson disease (PD) and melanoma, but its genetic variants do not play roles in susceptibility for Parkinson disease or rapid eye movement sleep behavior disorder. PMID: 27131830
    23. Variants in MC1R do not play a major role in PD in the Chinese population. PMID: 27084066
    24. Latin American families had CDKN2A mutations more frequently (P = 0.014) than Spanish ones. Of patients with SMP, 10% of those from Latin America and 8.5% of those from Spain had mutations in CDKN2A (P = 0.623). The most recurrent CDKN2A mutations were c.-34G>T and p.G101W. Latin American patients had fairer hair and skin) and a higher prevalence of MC1R variants compared with Spanish ones PMID: 26681309
    25. MC1R genetic effects might contribute to sex-specific differences in skin phototype PMID: 27637409
    26. MC1R may represent a common pathogenic pathway for melanoma and Parkinson disease. PMID: 28019657
    27. Carriers of MC1R variants were at increased melanoma risk independent of their sun exposure. PMID: 27050141
    28. This study confirms the presence of CDKN2A and MC1R variants among Cypriot melanomas and supports existing evidence of a role for these variants in susceptibility to melanoma. PMID: 28360400
    29. Presence of MC1R variant alleles predicted higher levels of dental fear and fear of pain. Importantly, fear of pain mediated the relation between MC1R variant status and dental fear. PMID: 27555332
    30. this case-control genetic association study using Taiwanese population showed that certain linkage disequilibrium structure of MC1R is strongly associated with vitiligo PMID: 26670452
    31. Case Report: MC4R p.Met215del coexisting with FTO and MC1R gene variants, causes severe early onset obesity. PMID: 27394708
    32. MC1R status is associated with BRAF(V600E), BRAF(V600K), and NRAS mutations in cutaneous melanomas PMID: 26807515
    33. Study found that HBD2 bound tightly to Mc1r with an affinity similar to that of HBD3 PMID: 26536271
    34. Six MC1R mutations segregated with the phenotype in seven families, including a p.Val174del in-frame deletion and a p.Tyr298* nonsense mutation, that were analyzed for function in heterologous HEK293 cells. PMID: 26197705
    35. Even after taking into account potential confounding effects of MC1R genotype and various lifestyle factors that close relatives may share, family history of skin cancer remained strongly associated with early-onset basal cell carcinoma PMID: 26381319
    36. Woman who carried a deleterious CDKN2A mutation and was also homozygous for the MC1R variant allele R160W developed 20 cutaneous melanomas in her lifetime. PMID: 26103950
    37. The pattern of sequence diversity here does not support a model of strong selective constraint on MC1R in Northern Island Melanesia. PMID: 26482799
    38. Functional characterization of MC1R-TUBB3 intergenic splice variants of the human melanocortin 1 receptor has been undertaken in response to ultraviolet irradiation. PMID: 26657157
    39. none of the three variants of the MC1R gene and related haplotypes be associated with sporadic form of Parkinson disease in Chinese Han population from Mainland China. PMID: 26628245
    40. MC1R genotype is a risk factor for the development of BCC in Greek patients independently of pigmentary characteristics, and the combination of MC1R variants may modulate this risk. PMID: 25809071
    41. Interestingly, we observed an increased risk of melanoma in subjects with darker skin and lower nevus count, usually considered at low risk, when carrying melanocortin 1 receptor polymorphisms. PMID: 25736238
    42. MC2R and MC1R signals are consecutively required for the regulation of EPO signal transduction in erythroblast differentiation, and MC5R signal transduction is required to induce enucleation. PMID: 25860801
    43. MC1-signaling protects against cartilage degradation and subchondral bone sclerosis in OA indicating a beneficial role of the POMC system in joint pathophysiology. PMID: 25191747
    44. The presence of two common variants of MC1R was identified as a risk factor for severe photoaging. PMID: 26067307
    45. ASIP diminishes agonist-independent MC1R basal signaling whereas HBD3 is a neutral MC1R antagonist that blocks activation by melanocortins. PMID: 26168232
    46. the inhibitory effects of alpha-MSH on inflammation are dependent on MC-1 R PMID: 25898835
    47. Our results suggest inherited variation in MC1R may play an influential role in anatomic site presentation of melanomas and may differ with respect to skin pigmentation phenotype. PMID: 25790105
    48. The computational analysis proved capable of identifying the potentially damaging non-synonymous single nucleotide polymorphisms in MC1R. PMID: 25794181
    49. MC1R mutations in this series demonstrated and inverse association for head and neck melanomas. PMID: 25385688
    50. MC1R polymorphism is associated in patients with pot-burn hypertrophic scarring. PMID: 26030184

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  • 相关疾病：
    Melanoma, cutaneous malignant 5 (CMM5)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in melanocytes. Expressed in corticoadrenal tissue.
  • 数据库链接：

    HGNC: 6929

    OMIM: 155555

    KEGG: hsa:4157

    STRING: 9606.ENSP00000451605

    UniGene: Hs.513829