ADAM9
ADAM9（A disintegrin and metalloprotease 9），即含有脱氨酸和金属蛋白酶结构域的蛋白9，是一种多功能的膜锚定蛋白，参与了多种生理过程。它由信号肽、金属蛋白酶结构域、脱氨酸结构域、富含半胱氨酸的结构域和类表皮生长因子样结构域组成。ADAM9在高尔基体运输至细胞膜的过程中，通过去除其抑制性原结构域而被激活，这一裂解过程由furin或前蛋白转化酶在两个PC位点进行。ADAM9的功能涉及细胞粘附、细胞表面蛋白的脱落，以及在发育、炎症和退行性疾病中的作用。特别地，ADAM9在肿瘤生物学中扮演着关键角色，其在多种癌症中的过表达与肿瘤的侵袭性和不良预后密切相关。ADAM9通过蛋白水解和非蛋白水解途径促进肿瘤的进展、治疗抗性和转移。它能够识别并释放膜结合的细胞因子和生长因子的胞外片段，同时参与受体和其他分子的信号转导。ADAM9在肿瘤增殖、血管生成和免疫逃逸等多个肿瘤过程中发挥作用。因此，ADAM9已成为炎症性疾病和癌症治疗中的潜在生物标志物和治疗靶点，针对其的治疗策略包括ADC药物、单克隆抗体和小分子抑制剂等正在开发中。
热销产品
ADAM9 Antibody (CSB-PA618774ESR1HU)
验证数据
Western blot
All lanes: Disintegrin and metalloproteinase domain-containing protein 9 antibody at 2μg/ml
Lane 1: Mouse liver tissue
Lane 2: Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 91, 73 kDa
Observed band size: 91 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA618774ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA618774ESR1HU at dilution of 1:100
ADAM9 Antibodies
ADAM9 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA618774ESR1HU | ADAM9 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA618774ESR2HU | ADAM9 Antibody | Human | ELISA, IHC |
ADAM9 Proteins
ADAM9 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP618774HU CSB-EP618774HU CSB-BP618774HU CSB-MP618774HU CSB-EP618774HU-B |
Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADAM9 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP730719MO CSB-EP730719MO CSB-BP730719MO CSB-MP730719MO CSB-EP730719MO-B |
Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 9 (Adam9), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADAM9 ELISA Kit
ADAM9 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E11904h | Human A Disintegrin And Metalloprotease 9,ADAM9 ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates, ascitic fluid | 15.6 pg/mL |
