ADA

ADA，即腺苷脱氨酶，是一种参与嘌呤代谢途径的关键酶（EC3.5.4.4）。它在人体中的主要功能是免疫系统的发育和维持，尤其在淋巴细胞和巨噬细胞中发挥作用。ADA的作用机制包括不可逆地催化腺苷脱去氨基，转化为肌苷，然后肌苷可进一步被嘌呤核苷磷酸化酶（PNP）转化为次黄嘌呤。ADA活性位点含有锌离子，该离子是ADA活性所必需的唯一辅助因子，底物腺苷通过多个氢键与活性位点结合并被催化。ADA在信号传导中的作用涉及到调节细胞内腺苷水平，腺苷是一种强效的免疫调节分子，通过其受体影响细胞功能。ADA的活性还与多种生理和病理过程相关，包括上皮细胞分化、神经传递以及妊娠维持等。在生物学意义上，ADA不仅在嘌呤补救途径中发挥关键作用，而且其活性的变化与多种疾病相关，例如ADA缺乏可导致严重联合免疫缺陷（SCID），而ADA活性的增加与某些癌症、自身免疫疾病以及HIV/AIDS有关。因此，ADA是免疫调节和疾病诊断中的一个重要生物标志物。

热销产品

ADA Antibody (CSB-PA240615)

验证数据

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA240615(ADA Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA240615(ADA Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA240615(ADA Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

Human adenosine deaminase,ADA ELISA Kit (CSB-E09613h)

验证数据

货号：CSB-E09613h

规格：96T/48T

灵敏度：0.39 mIU/mL

检测范围：1.56 mIU/mL-100 mIU/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ADA Antibody

ADA Protein

ADA ELISA Kit

ADA Antibodies

ADA for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA001268EA01HU	ADA Antibody	Human	ELISA, WB, IHC, IF
CSB-PA001268EB01HU	ADA Antibody, HRP conjugated	Human	ELISA
CSB-PA240615	ADA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA776767	ADA Antibody	Human,Mouse,Rat	ELISA,WB,IHC

ADA Proteins

ADA Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP001268HU CSB-EP001268HU CSB-BP001268HU CSB-MP001268HU CSB-EP001268HU-B	Recombinant Human Adenosine deaminase (ADA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli