Aldh1a2
ALDH1A2，即醛脱氢酶1家族成员A2，别名DIH4、RALDH2、RALDH2-T、RALDH(II)等。这是一种由人类基因编码的酶，主要参与视黄醇代谢的第二步，将视黄醛不可逆地氧化成视黄酸，是视黄酸的主要合成酶 。视黄酸是维生素A的活性衍生物，作为一种激素信号分子，在发育和成人组织中发挥作用，对胚胎发育和成体组织的维持至关重要 。ALDH1A2在生物学上的意义主要体现在其对视黄酸水平的调控作用。研究表明，ALDH1A2与细胞色素CYP26A1共同作用，建立局部胚胎视黄酸水平，促进后部器官的发育并预防脊柱裂的发生 。ALDH1A2的异常表达与多种疾病相关，包括神经管缺陷、小眼症、膈疝等 。此外，ALDH1A2在某些肿瘤干细胞中的表达增加，可能与肿瘤的发生发展有关 。因此，ALDH1A2是药物开发和疾病治疗中的一个潜在靶点。
热销产品
Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) (CSB-YP001566HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ALDH1A2 Antibody (CSB-PA001566EA01HU)
验证数据
Western Blot
Positive WB detected in: K562 whole cell lysate, Mouse kidney tissue
All lanes: ALDH1A2 antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 54, 55, 47 kDa
Observed band size: 54 kDa
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA001566EA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001566EA01HU at dilution of 1:100
Aldh1a2 Antibodies
Aldh1a2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA001566GA01HU | ALDH1A2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA001566ESR1HU | ALDH1A2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA001566ESR2HU | ALDH1A2 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA144510 | ALDH1A2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA070161 | ALDH1A2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA053602 | ALDH1A2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA039662 | ALDH1A2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001566EA01HU | ALDH1A2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA001566ED01HU | ALDH1A2 Antibody, Biotin conjugated | Human | ELISA |
Aldh1a2 Proteins
Aldh1a2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001566HU | Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) | Yeast |
| CSB-EP001566HU CSB-BP001566HU CSB-MP001566HU CSB-EP001566HU-B |
Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
