CDC123
CDC123,即细胞分裂周期12蛋白,别名细胞分裂周期相关蛋白。CDC123是一种高度保守的蛋白质,在多种生物体中都有发现,包括人类、小鼠、果蝇和酵母等。它在细胞周期调控、蛋白质折叠和应对细胞应激中发挥重要作用。CDC123的作用机制涉及到与多种蛋白质的相互作用,包括与HSP90分子伴侣的结合,以及参与内质网相关降解(ERAD)过程,帮助维持蛋白质稳态和细胞内环境平衡。CDC123在生物学上的意义非常广泛,它参与了多种细胞内信号通路,包括细胞周期进程、蛋白质合成、内质网应激反应等。CDC123的功能异常与多种疾病有关,包括某些类型的癌症、神经退行性疾病和代谢性疾病。例如,在肿瘤细胞中,CDC123的表达水平可能与肿瘤的增殖、侵袭和转移能力相关。此外,CDC123还可能参与调节细胞对营养缺乏和氧化应激的响应,影响细胞的生存和死亡。因此,CDC123是细胞生物学研究和相关疾病治疗中的一个潜在靶点 。
热销产品
CDC123 Antibody (CSB-PA004984LA01HU)
验证数据
IHC image of CSB-PA004984LA01HU diluted at 1:500 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
CDC123 Antibodies
CDC123 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA004984LA01HU | CDC123 Antibody | Human | ELISA, IHC |
CDC123 Proteins
CDC123 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP004984HU CSB-EP004984HU CSB-BP004984HU CSB-MP004984HU CSB-EP004984HU-B |
Recombinant Human Cell division cycle protein 123 homolog (CDC123) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |