CDK12
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
CDK12 Antibodies
CDK12 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA998940 | CDK12 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA882147LA01HU | CDK12 Antibody | Human | ELISA, WB |
CDK12 Proteins
CDK12 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005981XBF CSB-EP005981XBF CSB-BP005981XBF CSB-MP005981XBF CSB-EP005981XBF-B |
Recombinant Xenopus tropicalis Cyclin-dependent kinase 12 (cdk12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Ailuropoda melanoleuca (Giant panda)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005981AYX CSB-EP005981AYX CSB-BP005981AYX CSB-MP005981AYX CSB-EP005981AYX-B |
Recombinant Ailuropoda melanoleuca Cyclin-dependent kinase 12 (CDK12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005981BO CSB-EP005981BO CSB-BP005981BO CSB-MP005981BO CSB-EP005981BO-B |
Recombinant Bovine Cyclin-dependent kinase 12 (CDK12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP622934MO CSB-EP622934MO CSB-BP622934MO CSB-MP622934MO CSB-EP622934MO-B |
Recombinant Mouse Cyclin-dependent kinase 12 (Cdk12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP659533RA CSB-EP659533RA CSB-BP659533RA CSB-MP659533RA CSB-EP659533RA-B |
Recombinant Rat Cyclin-dependent kinase 12 (Cdk12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP882147HU CSB-EP882147HU CSB-BP882147HU CSB-MP882147HU CSB-EP882147HU-B |
Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDK12 Proteins for Drosophila melanogaster (Fruit fly)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP894718DLU CSB-BP894718DLU CSB-MP894718DLU CSB-EP894718DLU-B |
Recombinant Drosophila melanogaster Cyclin-dependent kinase 12 (Cdk12), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
