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CLDN6

CLDN6:癌症治疗新宠

CLDN6位于染色体16p3.3,分子量大约20-40kDa。Claudins成员之间具有相似的结构,每个Claudin分子有4个跨膜结构域,2个细胞外环和2条胞内尾区。CLDN6拥有一个C端的PDZ结合位点,使得紧密连接蛋白能与细胞内某些蛋白发生相互作用关系,在细胞连接及上皮组织通透性等方面均可发挥重要作用

越来越多的研究表明,CLDN6异常表达可参与乳腺癌,卵巢癌,宫颈癌,胃癌,肺癌等多种恶性肿瘤发生及发展过程。CLDN6作为细胞骨架的形成和细胞信号通路调节的重要分子,可影响细胞的生长进程,这为肿瘤的诊断和干预提供了新的方向。目前,多款针对CLDN6的药物已处于临床和临床前阶段,用于多种肿瘤的治疗。

CUSABIO-哺乳包膜VIPs平台成功开发CLDN6全长跨膜蛋白(4次跨膜),展示了完整生物活性。

热销产品

Recombinant Human Claudin-6(CLDN6)-VLPs (Active) (CSB-MP005508HU(A4))

验证数据

WB
CSB-MP005508HU(A4) WB

CSB-MP005508HU(A4) is detected by Mouse anti-6*His monoclonal antibody.

ELISA
CSB-MP005508HU(A4) ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 at 10 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC50 is 1.501-2.035 ng/mL

TEM
CSB-MP005508HU(A4) TEM

The presence of VLP-like structures was confirmed by TEM

CLDN6/9 Recombinant Monoclonal Antibody CSB-RA005508MA1HU

验证数据

ELISA
CSB-RA005508MA1HU ELISA

The Binding Activity of Huamn CLDN6 with Anti-CLDN6/9 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A4)) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 1.501-2.035 ng/mL.

ELISA
CSB-RA005508MA1HU ELISA

The Binding Activity of Human CLDN9 with Anti-CLDN6/9 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 (CSB-MP005511HU) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 24.93-35.47 ng/mL.

TEM
RA005508MA1HU FC

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 recombinant antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CLDN6 Antibodies

CLDN6 for Homo sapiens (Human)

CLDN6 Proteins

CLDN6 Proteins for Homo sapiens (Human)

CLDN6 Proteins for Homo sapiens(Human)