DMPK

DMPK，即肌营养不良蛋白激酶，是一种关键的蛋白激酶，具有特定的结构域，包括催化域和调节域，这些结构域共同决定了其激酶活性和底物特异性。在功能上，DMPK通过磷酸化蛋白质底物来调节肌肉功能和其他生理活动，包括肌肉收缩、细胞增殖、分化以及凋亡等过程。当DMPK的表达或功能发生异常时，可能会引发多种疾病，特别是肌强直性营养不良症，这是一种遗传性肌肉疾病，表现为肌肉无力、肌强直和心肌功能障碍等症状。在信号通路上，DMPK与其他信号分子和蛋白质相互作用，共同构成复杂的信号网络，涉及钙离子信号通路、MAPK信号通路等，从而维持细胞稳态并应对外界刺激。

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DMPK Antibody

验证数据

Immunofluorescence staining of A549 cells with CSB-PA006968LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

IHC image of CSB-PA006968LA01HU diluted at 1:500 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA006968LA01HU diluted at 1:500 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

DMPK Antibody