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EGLN3

Egl nine homolog 3 is a protein in humans that is encoded by EGLN3 gene. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

EGLN3 Antibodies

EGLN3 for Mus musculus (Mouse)

EGLN3 for Homo sapiens (Human)

EGLN3 Proteins

EGLN3 Proteins for Rattus norvegicus (Rat)

EGLN3 Proteins for Mus musculus (Mouse)

EGLN3 Proteins for Homo sapiens (Human)