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EIF3A

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

EIF3A Antibodies

EIF3A for Homo sapiens (Human)

EIF3A Proteins

EIF3A Proteins for Mus musculus (Mouse)

EIF3A Proteins for Xenopus laevis (African clawed frog)

EIF3A Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

EIF3A Proteins for Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)

EIF3A Proteins for Drosophila ananassae (Fruit fly)

EIF3A Proteins for Drosophila erecta (Fruit fly)

EIF3A Proteins for Drosophila simulans (Fruit fly)

EIF3A Proteins for Drosophila virilis (Fruit fly)

EIF3A Proteins for Drosophila willistoni (Fruit fly)

EIF3A Proteins for Drosophila sechellia (Fruit fly)

EIF3A Proteins for Drosophila persimilis (Fruit fly)

EIF3A Proteins for Drosophila mojavensis (Fruit fly)

EIF3A Proteins for Drosophila yakuba (Fruit fly)

EIF3A Proteins for Homo sapiens (Human)

EIF3A Proteins for Rattus norvegicus (Rat)

EIF3A Proteins for Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

EIF3A Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

EIF3A Proteins for Dictyostelium discoideum (Slime mold)

EIF3A Proteins for Drosophila melanogaster (Fruit fly)