Epha3
EphA3属于Eph受体家族的一员，被认为是细胞粘附和迁移的调节器。EphA3最初是从前B淋巴白血病细胞表面（ALL）细胞系（LK63）中分离得到的表面抗原。EphA3在大脑和脊髓，肺，肾，心脏和肌肉组织的胚胎发育的各个阶段高度表达。在正常成人组织中EphA3几乎不存在，并且在中枢神经系统（CNS）中稀疏表达，在视网膜中表达相对较高，在膀胱，前列腺，子宫和心脏中的表达较少。EphA3在胃癌、肺癌、肾癌、结肠癌、黑色素瘤、肉瘤、胆管癌、前列腺癌等实体肿瘤中异常表达，并且与肿瘤的侵袭转移相关。EphA3的配体包括Ephrin-B2和Ephrin-A5。EphA3与配体结合，在正常细胞黏附、迁移、血管生成中发挥重要的作用，研究表明Eph受体或ephrin蛋白在维持血管、肾脏及肠道等组织的结构上发挥着一定的作用。此外，它们还和许多肿瘤血管的形成密切相关，并被认为参与肿瘤的侵袭和转移。
Recombinant Human EPHA3 活性蛋白实验验证数据
SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized EPHA3 at 2 μg/ml can bind human EFNA5(CSB-MP007464HU), the EC50 of the protein is 0.9734-1.179 ng/ml.
Human EPHA3 protein his tag (CSB-MP007723HU) captured on COOH chip can bind Human EFNA5 protein Fc tag (CSB-MP007464HU) with an affinity constant of 13.8 nM as detected by LSPR Assay.
Epha3 Antibodies
Epha3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA159480 | Phospho-EPHA3 (Tyr779/833) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA030077 | EPHA3 (Ab-602) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA298527 | EPHA3 Antibody | Human | ELISA,WB |
| CSB-PA008057 | EPHA3 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008060 | EPHA3 Antibody | Human,Mouse,Rat | WB, ELISA |
Epha3 Proteins
Epha3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007723HU CSB-EP007723HU CSB-BP007723HU CSB-EP007723HU-B |
Recombinant Human Ephrin type-A receptor 3 (EPHA3), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP007723HU | Recombinant Human Ephrin type-A receptor 3 (EPHA3), partial (Active) | Mammalian cell |
Epha3 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007723MO CSB-EP007723MO CSB-BP007723MO CSB-MP007723MO CSB-EP007723MO-B |
Recombinant Mouse Ephrin type-A receptor 3 (Epha3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Epha3 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007723CH CSB-EP007723CH CSB-BP007723CH CSB-MP007723CH CSB-EP007723CH-B |
Recombinant Chicken Ephrin type-A receptor 3 (EPHA3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Epha3 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007723RA CSB-EP007723RA CSB-BP007723RA CSB-MP007723RA CSB-EP007723RA-B |
Recombinant Rat Ephrin type-A receptor 3 (Epha3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Epha3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007723DIL CSB-EP007723DIL CSB-BP007723DIL CSB-MP007723DIL CSB-EP007723DIL-B |
Recombinant Danio rerio Ephrin type-A receptor 3 (epha3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
