FKBP1A
FKBP1A，即FKBP脯氨酸异构酶1A，别名FKBP12。它是一种在细胞内具有多种生物学功能的蛋白质，由人体细胞自身的基因编码。FKBP1A的作用机制涉及到其作为顺式/反式肽基脯氨酰异构酶(cis/trans peptidyl prolyl isomerase, PPIase)的活性，这种酶能够催化蛋白质肽链中脯氨酸残基的顺式和反式构象的相互转换，从而参与蛋白质的折叠和稳定性调节。FKBP1A还参与调节包括mTOR/AKT信号通路在内的多种信号传导途径。FKBP1A在生物学上的意义主要体现在其参与调节的多种细胞生理过程，包括细胞增殖、代谢、免疫反应等。在肿瘤生物学中，FKBP1A被发现在多种癌症中表达上调，并与肿瘤的恶性行为相关。例如，在胃癌中，FKBP1A的高表达与患者的不良预后相关，并且可能通过激活PI3K/AKT信号通路来促进癌细胞的糖代谢和恶性生物学行为。此外，FKBP1A还涉及炎症相关信号通路的调节，对炎症、适应性免疫反应、癌症和发育生物学等过程具有重要作用。
热销产品
Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A), partial (CSB-EP008691HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FKBP1A Antibody (CSB-PA02325A0Rb)
验证数据
Western blot
All lanes: FKBP1A antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 12 kDa
Observed band size: 12 kDa
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA02325A0Rb at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA02325A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
FKBP1A Antibodies
FKBP1A for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA02325A0Rb | FKBP1A Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA02325B0Rb | FKBP1A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA02325D0Rb | FKBP1A Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA008691GA01HU | FKBP1A Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
FKBP1A Proteins
FKBP1A Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008691HU CSB-EP008691HU CSB-BP008691HU CSB-MP008691HU CSB-EP008691HU-B |
Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008691HU1 | Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A), partial | E.coli |
