Fgf21

FGF21，即成纤维细胞生长因子21，别名FGF-21。FGF21是一种由肝脏和其他代谢活跃组织产生的应激诱导型激素，属于成纤维细胞生长因子家族的新成员。FGF21通过与成纤维细胞生长因子受体（FGFR）1c、2c和3c结合，并需要β-Klotho作为辅助因子来激活多种细胞内信号通路，发挥其生物学作用。其主要作用包括促进脂肪酸氧化、调节能量消耗、增加葡萄糖摄取、促进脂肪细胞因子分泌和调节脂质代谢。FGF21在生物学上的意义非常广泛，它在减轻肝脏应激、保护肝细胞、抑制细胞凋亡和炎症信号、以及抑制肝星状细胞分化为胶原蛋白分泌的肌成纤维细胞方面发挥作用。FGF21还与其他激素如胰岛素、胰高血糖素和甲状腺激素相互作用，以调节全身和肝脏的代谢。此外，FGF21的激动剂在治疗代谢功能障碍相关脂肪肝炎（MASH）中显示出潜力，能够改善代谢功能和脂质代谢，并在临床前模型中减少肝脂肪含量、改善肝脏组织学特征。FGF21的激动剂，如efruxifermin和pegozafermin，正在开发中，并在多个代谢疾病适应症中进行了研究，包括肥胖、高甘油三酯血症、血脂异常、2型糖尿病和代谢功能障碍相关脂肪肝病/代谢功能障碍相关脂肪肝炎。

热销产品

Recombinant Human Fibroblast growth factor 21 (FGF21) (CSB-EP008627HU)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FGF21 Antibody (CSB-PA06404A0Rb)

验证数据

Western blot
All lanes: FGF21 antibody at 2µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 23 kDa
Observed band size: 23 kDa

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA06404A0Rb at dilution of 1:100

Fgf21 Antibody

Fgf21 Protein

Fgf21 ELISA Kit

Fgf21 Antibodies

Fgf21 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA06404A0Rb	FGF21 Antibody	Human	ELISA, WB, IHC
CSB-PA06404D0Rb	FGF21 Antibody, Biotin conjugated	Human	ELISA
CSB-PA06404B0Rb	FGF21 Antibody, HRP conjugated	Human	ELISA
CSB-PA290047	FGF21 Antibody	Human,Mouse	ELISA,IHC
CSB-PA876229	FGF21 Antibody	Human,Mouse	ELISA,IHC

Fgf21 for Mus musculus (Mouse)

产品货号	产品名称	种属反应性	应用类型
CSB-PA008627LA01MO	Fgf21 Antibody	Mouse	ELISA
CSB-PA008627LC01MO	Fgf21 Antibody, FITC conjugated	Mouse
CSB-PA008627LD01MO	Fgf21 Antibody, Biotin conjugated	Mouse	ELISA

Fgf21 Proteins

Fgf21 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-EP008627HU	Recombinant Human Fibroblast growth factor 21 (FGF21)	E.coli
CSB-YP008627HU CSB-EP008627HU CSB-BP008627HU CSB-MP008627HU CSB-EP008627HU-B	Recombinant Human Fibroblast growth factor 21 (FGF21)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP002471HU	Recombinant Human Fibroblast growth factor 21 protein (FGF21)	E.Coli

Fgf21 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP008627MO CSB-BP008627MO CSB-MP008627MO CSB-EP008627MO-B	Recombinant Mouse Fibroblast growth factor 21 (Fgf21)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP008627MO	Recombinant Mouse Fibroblast growth factor 21 (Fgf21)	E.coli