Gpr84
GPR84是一种G蛋白偶联受体，即中链脂肪酸受体。它在多种细胞类型中表达，包括中性粒细胞等免疫细胞。GPR84的作用机制涉及通过与脂肪酸等配体结合，激活下游信号通路，影响细胞的迁移、脱颗粒和氧化应激反应。在信号传导方面，GPR84能够通过Lyn-AKT/ERK通路进行信号转导，进而调控氧化应激关键蛋白p47PHOX的活性，参与活性氧簇（ROS）的产生。在生物学意义上，GPR84参与调控炎症反应和免疫应答，尤其在急性肺损伤（ALI）等疾病中发挥重要作用，其表达的变化与肺部炎症因子水平、肺组织损伤程度密切相关。因此，GPR84被认为是治疗急性肺损伤等炎症性疾病的潜在药物靶点。
热销产品
Recombinant Human G-protein coupled receptor 84 (GPR84), partial (CSB-YP865107HU2)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of GPR84 was greater than 90% as determined by SEC-HPLC
GPR84 Antibody (CSB-PA865107LA01HU)
验证数据
Immunofluorescent analysis of Hela cells using CSB-PA865107LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Gpr84 Antibodies
Gpr84 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA865107LA01HU | GPR84 Antibody | Human | ELISA, IF |
| CSB-PA865107LB01HU | GPR84 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA865107LC01HU | GPR84 Antibody, FITC conjugated | Human | |
| CSB-PA865107LD01HU | GPR84 Antibody, Biotin conjugated | Human | ELISA |
Gpr84 Proteins
Gpr84 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP644417BO1 CSB-EP644417BO1 CSB-BP644417BO1 CSB-MP644417BO1 CSB-EP644417BO1-B |
Recombinant Bovine G-protein coupled receptor 84 (GPR84), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF644417BO | Recombinant Bovine G-protein coupled receptor 84 (GPR84) | in vitro E.coli expression system |
Gpr84 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP807541MO1 CSB-EP807541MO1 CSB-BP807541MO1 CSB-MP807541MO1 CSB-EP807541MO1-B |
Recombinant Mouse G-protein coupled receptor 84 (Gpr84), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF807541MO | Recombinant Mouse G-protein coupled receptor 84 (Gpr84) | in vitro E.coli expression system |
Gpr84 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP865107HU1 CSB-EP865107HU1 CSB-BP865107HU1 CSB-MP865107HU1 CSB-EP865107HU1-B |
Recombinant Human G-protein coupled receptor 84 (GPR84), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF865107HU | Recombinant Human G-protein coupled receptor 84 (GPR84) | in vitro E.coli expression system |
| CSB-YP865107HU2 | Recombinant Human G-protein coupled receptor 84 (GPR84), partial | Yeast |
