IDO1
IDO1,即吲哚胺2,3-双加氧酶1,它是一种由IDO1基因编码的酶,主要分布在肝脏外的各种组织和细胞中,如胸腺、小肠、附睾、胎盘、肾脏、脾脏、胰腺、中枢神经系统等。IDO1的主要作用机制是催化色氨酸转化为犬尿氨酸,这一过程是色氨酸代谢的限速步骤。在信号通路方面,IDO1的活性受到多种细胞因子如IFN-γ、TNF-α的调控,这些细胞因子通过作用于IDO1基因的干扰素刺激反应元素(GAS)和干扰素激活位点(ISRE)来诱导IDO1的表达。在生物学意义上,IDO1在维持免疫稳态、调节免疫应答中发挥重要作用,尤其是在妊娠期间防止胎儿排斥反应、肿瘤免疫逃逸、以及某些感染性疾病中。IDO1的异常表达或活性与多种疾病包括肿瘤、自身免疫病和神经退行性疾病等的发生发展密切相关。
热销产品
Recombinant Human Indoleamine 2,3-dioxygenase 1 (IDO1) (CSB-EP010996HU)
验证数据
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010996HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IDO1.
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Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010996HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IDO1.
IDO1 Recombinant Monoclonal Antibody (CSB-RA215054A0HU)
验证数据
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IHC image of CSB-RA215054A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Mouse Indoleamine 2,3-dioxygenase 1(IDO1) ELISA kit (CSB-EL010996MO)
验证数据
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货号:CSB-EL010996MO
规格:96T/48T
灵敏度:15.6 pg/mL
检测范围:62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IDO1 Antibodies
IDO1 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA010996GA01HU | IDO1 Antibody | Human | ELISA,WB |
CSB-PA010996HD01HU | IDO1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA010996HC01HU | IDO1 Antibody, FITC conjugated | Human | |
CSB-PA010996HB01HU | IDO1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA010996HA01HU | IDO1 Antibody | Human | ELISA, WB, IHC, IF |
CSB-RA215054A0HU | IDO1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
IDO1 Proteins
IDO1 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP010996HU | Recombinant Human Indoleamine 2,3-dioxygenase 1 (IDO1) | Yeast |
CSB-EP010996HU | Recombinant Human Indoleamine 2,3-dioxygenase 1 (IDO1) | E.coli |
CSB-BP010996HU CSB-MP010996HU CSB-EP010996HU-B |
Recombinant Human Indoleamine 2,3-dioxygenase 1 (IDO1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IDO1 ELISA Kit
IDO1 ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E09966h | Human indoleamine 2,3-dioxygenase,IDO ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.195 ng/mL |