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IL15

IL15,即白细胞介素15,它主要由单核细胞和巨噬细胞产生,人体多种组织如心、肺、肾以及胎盘和肌肉等都能表达IL-15 mRNA。IL15的作用机制涉及与其特异性受体IL-15Rα结合,形成免疫突触,并激活JAK1/JAK3和STAT3/STAT5途径、Syk激酶和磷脂酶C(PLC)γ等,导致PI3K/Akt和Ras/Raf/MAPK信号级联的激活。在生物学意义上,IL15具有调节T细胞、B细胞、NK细胞和CTL功能,刺激这些细胞的增殖,并在促炎症、抗肿瘤、抗感染中发挥重要作用。IL15与IL-2功能相似但具有不同的受体结构和信号转导通路,IL15的优势在于不会引起活化T细胞的凋亡,并能维持记忆性T细胞,对长期抗肿瘤活性起到关键作用。

IL15 Antibodies

IL15 for Homo sapiens (Human)

IL15 Proteins

IL15 Proteins for Mus musculus (Mouse)

IL15 Proteins for Macaca mulatta (Rhesus macaque)

IL15 Proteins for Felis catus (Cat) (Felis silvestris catus)

IL15 Proteins for Homo sapiens (Human)

IL15 Proteins for Rattus norvegicus (Rat)

IL15 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

IL15 Proteins for Marmota himalayana (Himalayan marmot)

IL15 Proteins for Ailuropoda melanoleuca (Giant panda)

IL15 Proteins for Bos taurus (Bovine)

IL15 Proteins for Oryctolagus cuniculus (Rabbit)

IL15 Proteins for Bubalus bubalis (Domestic water buffalo)

IL15 Proteins for Macaca thibetana (Pere David's macaque) (Tibetan macaque)

IL15 Proteins for Marmota monax (Woodchuck)

IL15 Proteins for Cavia porcellus (Guinea pig)

IL15 Proteins for Sus scrofa (Pig)

IL15 Proteins for Ovis aries (Sheep)

IL15 ELISA Kit

IL15 ELISA Kit for Homo sapiens (Human)

IL15 ELISA Kit for Monkey

IL15 ELISA Kit for Mus musculus (Mouse)

IL15 ELISA Kit for Sus scrofa (Pig)

IL15 ELISA Kit for Rattus norvegicus (Rat)