IL4R
IL-4R由802个氨基酸残基组成，分子量为140kDa，属于红细胞生成素受体超家族成员。其结构具有特定的特征，包括两个纤连蛋白结构域（fnIII），每个结构域由六个β片组成。在IL-4与IL-4Rα亚基结合时，这些结构域有助于形成异二聚体。IL-4R在多种细胞过程中扮演重要角色。它参与免疫细胞的存活、发育，调控B细胞的发育和成熟，以及Ⅱ型辅助性T细胞的增殖分化。此外，IL-4R的表达与多种肿瘤细胞的存活、增殖、迁移和侵袭密切相关。在肿瘤微环境中，IL-4R的表达上调，并通过多种机制促进肿瘤转移。 IL-4R的生物学功能主要通过非受体型酪氨酸激酶JAK激活。当IL-4与IL-4R结合时，它会激活JAK，进而触发一系列的信号级联反应。这些反应包括STAT6的磷酸化和核转位，以及其他下游信号分子的激活。这些信号通路最终影响细胞的增殖、分化、存活和迁移等过程。
热销产品
● Recombinant Human Interleukin-4 receptor subunit alpha(IL4R), partial,Biotinylated (Active)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL4(CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R，the EC50 is 12.68-14.23 ng/mL.
● Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
● Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL4R Antibodies
IL4R for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA003031 | IL4R Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA009554 | Phospho-IL4R (Y497) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA009556 | IL4R Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA512009 | IL4R Antibody | Human | WB, ELISA |
IL4R Proteins
IL4R Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011661MO1 CSB-EP011661MO1 CSB-BP011661MO1 CSB-MP011661MO1 CSB-EP011661MO1-B |
Recombinant Mouse Interleukin-4 receptor subunit alpha (Il4r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011661MO | Recombinant Mouse Interleukin-4 receptor subunit alpha (Il4r) | in vitro E.coli expression system |
IL4R Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011661HU1 CSB-BP011661HU1 CSB-EP011661HU1-B |
Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF011661HU | Recombinant Human Interleukin-4 receptor subunit alpha (IL4R) | in vitro E.coli expression system |
| CSB-AP004271HU | Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial (Active) | Mammalian cell |
| CSB-AP004281HU | Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial (Active) | Mammalian cell |
| CSB-EP011661HU1b0 | Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial | E.coli |
| CSB-EP011661HU1 | Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial | E.coli |
| CSB-MP011661HU1 | Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial | Mammalian cell |
| CSB-MP011661HU2-B | Recombinant Human Interleukin-4 receptor subunit alpha(IL4R), partial,Biotinylated (Active) | Mammalian cell |
IL4R Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP717364RA CSB-EP717364RA CSB-BP717364RA CSB-MP717364RA CSB-EP717364RA-B |
Recombinant Rat Interleukin-4 receptor subunit alpha (Il4r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL4R Proteins for Equus caballus (Horse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP751043HO CSB-EP751043HO CSB-BP751043HO CSB-MP751043HO CSB-EP751043HO-B |
Recombinant Horse Interleukin-4 receptor subunit alpha (IL4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL4R Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP771258PI | Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R), partial | Yeast |
| CSB-EP771258PI | Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R),Partial | E.coli |
| CSB-BP771258PI CSB-MP771258PI CSB-EP771258PI-B |
Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP771258PIa4 | Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R), partial | Yeast |
