Il17rb
IL17RB,即白介素17受体B”,别名IL-17RB。它是一种I型跨膜蛋白,属于IL-17受体家族成员之一,由人体细胞自身的基因编码。IL17RB的作用机制涉及到与特定的配体如IL-25(也称为IL-17E)结合,这一结合激活了下游的信号传导途径。IL17RB与IL-17RA一起参与形成功能性的受体复合物,这种复合物对于IL-25的信号传导至关重要。IL17RB通过其细胞外的纤连蛋白III型结构域与配体结合,并通过其细胞质内的SEFIR结构域传递信号,激活细胞内的信号通路。IL17RB在生物学上的意义主要体现在其参与调节免疫反应和炎症过程。作为IL-25的受体之一,IL17RB在Th2型免疫应答中发挥重要作用,影响过敏性疾病如哮喘和过敏性皮炎的病理过程。此外,IL17RB还与肿瘤发展相关,例如在乳腺癌中,IL17RB信号通路的激活可能促进肿瘤细胞的增殖和存活,因此靶向IL17RB信号通路可能成为抑制该疾病的一种潜在治疗策略。IL17RB的活性还与多种细胞因子和趋化因子的产生相关,通过激活MAPK、NF-κB和C/EBPs等信号途径,进而影响宿主的免疫反应。
热销产品
IL17RB Antibody (CSB-PA882088ESR1HU)
验证数据
Western blot
All lanes: IL17RB antibody at 2.16µg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56, 32 kDa
Observed band size: 56, 32 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA882088ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA882088ESR1HU at dilution of 1:100
Il17rb Antibodies
Il17rb for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA011603GA01HU | IL17RB Antibody | Human | ELISA,WB,IHC,IF |
CSB-PA891383 | IL17RB Antibody | Human | ELISA,IHC |
CSB-PA121041 | IL17RB Antibody | Human | ELISA,WB,IHC |
CSB-PA882088ESR1HU | IL17RB Antibody | Human | ELISA, WB, IHC |
CSB-PA882088ESR2HU | IL17RB Antibody | Human | ELISA, IHC |
Il17rb Proteins
Il17rb Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP872844MO CSB-EP872844MO CSB-BP872844MO CSB-MP872844MO CSB-EP872844MO-B |
Recombinant Mouse Interleukin-17 receptor B (Il17rb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Il17rb Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP882088HU CSB-EP882088HU CSB-BP882088HU CSB-MP882088HU CSB-EP882088HU-B |
Recombinant Human Interleukin-17 receptor B (IL17RB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Il17rb ELISA Kit
Il17rb ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL011603HU | Human Interleukin-17 receptor B(IL17RB) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/ml |