Lilrb4
LILRB4（白细胞免疫球蛋白样受体B4）是一种免疫检查点分子，属于白细胞免疫球蛋白样受体家族B亚家族成员。它由胞外免疫球蛋白样结构域、一个跨膜结构域以及含有免疫受体酪氨酸抑制基序（ITIMs）的细胞质结构域组成。LILRB4在多种免疫细胞上表达，包括单核细胞、巨噬细胞、肥大细胞、B细胞、自然杀伤细胞、T细胞和树突细胞等，具有调控免疫细胞活性、促进肿瘤免疫逃逸的功能。LILRB4通过与配体如整合素αvβ3结合，抑制肥大细胞活化，并通过其胞质结构域中的ITIMs传递抑制信号，抑制免疫细胞活性。此外，LILRB4还可能通过招募SHP1来抑制NF-κB信号通路，这在动脉粥样硬化的发生中可能起抑制作用。LILRB4的表达和功能在不同疾病中具有重要意义，尤其是在癌症治疗中，靶向LILRB4的抗体可能有助于抑制肿瘤免疫逃逸，提高免疫治疗的效果。因此，LILRB4是免疫治疗研究中的一个潜在靶点，其结构和功能的研究有助于开发新的治疗策略。
热销产品
LILRB4 Antibody (CSB-PA850914ESR2HU)
验证数据
Western Blot
Positive WB detected in: A549 whole cell lysate, THP-1 whole cell lysate
All lanes: LILRB4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa
IHC image of CSB-PA850914ESR2HU diluted at 1:250 and staining in paraffin-embedded human colorectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Lilrb4 Antibodies
Lilrb4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA297929 | LILRB4 Antibody | Human | ELISA,IF |
| CSB-PA006757 | LILRB4 Antibody | Human | IF, ELISA |
| CSB-PA850914ESR1HU | LILRB4 Antibody | Human | ELISA, WB |
| CSB-PA850914ESR2HU | LILRB4 Antibody | Human | ELISA, WB, IHC |
Lilrb4 Proteins
Lilrb4 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP731041MO CSB-EP731041MO CSB-BP731041MO CSB-MP731041MO CSB-EP731041MO-B |
Recombinant Mouse Leukocyte immunoglobulin-like receptor subfamily B member 4 (Lilrb4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Lilrb4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP850914HU CSB-EP850914HU CSB-BP850914HU CSB-MP850914HU CSB-EP850914HU-B |
Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Lilrb4 ELISA Kit
Lilrb4 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E11812h | Human leukocyte immunoglobulin-like receptor subfamily B member 4,LILRB4 ELISA Kit | serum, plasma, cell culture supernates, cell lysates | 7.81 pg/mL |
