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Mgrn1

E3 ubiquitin-protein ligase MGRN1 is a protein in humans that is encoded by MGRN1 gene. E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.

Mgrn1 Antibodies

Mgrn1 for Homo sapiens (Human)

Mgrn1 Proteins

Mgrn1 Proteins for Homo sapiens (Human)

Mgrn1 Proteins for Rattus norvegicus (Rat)

Mgrn1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Mgrn1 Proteins for Mus musculus (Mouse)