Nfe2l2

NFE2L2，即核因子（红细胞衍生2）相关因子2，别名NRF2、NFE2L2。它是一种转录因子，由人体细胞自身的基因编码，在细胞防御氧化应激和清除有害物质中发挥关键作用。NFE2L2的作用机制涉及多个层面，包括翻译后修饰、蛋白相互作用和表观遗传调控等。在正常生理条件下，NFE2L2与KEAP1结合并通过泛素-蛋白酶体途径促进其降解，维持NFE2L2表达在较低水平。当细胞遭遇氧化应激或亲电试剂时，NFE2L2会从细胞质转移到细胞核，与抗氧化反应元件(ARE)结合，激活抗氧化相关基因的转录。NFE2L2在生物学上的意义非常广泛，它参与调控黄曲霉毒素分解代谢过程、大分子代谢过程的正向调控以及细胞迁移的调节。NFE2L2的功能异常与多种疾病相关，包括糖尿病视网膜病变、肝硬化、大脑中动脉梗塞、非酒精性脂肪肝病等。此外，NFE2L2的人类直系同源基因与阿尔茨海默病、白内障、肝细胞癌、黄斑变性、肺结核等疾病有关。在癌症中，NFE2L2-KEAP1信号通路经常被劫持，尤其是在非小细胞肺癌中，NFE2L2的激活可导致癌细胞逃脱各种抗肿瘤治疗，促进疾病进展和转移。因此，NFE2L2是细胞氧化应激反应和疾病治疗中的一个重要靶点。

热销产品

Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial (CSB-EP614961HU1)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NFE2L2 Recombinant Monoclonal Antibody (CSB-RA225569A0HU)

验证数据

Immunofluorescence staining of Hela Cells with CSB-RA225569A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Nfe2l2 Antibody

Nfe2l2 Protein

Nfe2l2 ELISA Kit

Nfe2l2 Antibodies

Nfe2l2 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA009136GA01HU	NFE2L2 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA828758	NFE2L2 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA000152	Acetyl-NFE2L2 (K599) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA003481	NFE2L2 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA005517	NFE2L2 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA080280	NFE2L2 Antibody	Human,Mouse,Rat	WB, IHC
CSB-PA777170	NFE2L2 Antibody	Human,Mouse,Rat	IHC,ELISA
CSB-RA614961A40phHU	Phospho-NFE2L2 (S40) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF
CSB-PA614961LA01HU	NFE2L2 Antibody	Human	ELISA, IF
CSB-PA614961LB01HU	NFE2L2 Antibody, HRP conjugated	Human	ELISA
CSB-PA614961LC01HU	NFE2L2 Antibody, FITC conjugated	Human
CSB-PA614961LD01HU	NFE2L2 Antibody, Biotin conjugated	Human	ELISA
CSB-RA225569A0HU	NFE2L2 Recombinant Monoclonal Antibody	Human	ELISA, IF
CSB-MA614961A0m	NFE2L2 Monoclonal Antibody	Human, Mouse	ELISA, WB, IHC, IF, FC

Nfe2l2 Proteins

Nfe2l2 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP015752RA CSB-EP015752RA CSB-BP015752RA CSB-MP015752RA CSB-EP015752RA-B	Recombinant Rat Nuclear factor erythroid 2-related factor 2 (Nfe2l2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Nfe2l2 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP614961HU CSB-BP614961HU CSB-MP614961HU CSB-EP614961HU-B	Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP614961HU	Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2)	E.coli
CSB-EP614961HU1	Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial	E.coli

Nfe2l2 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP708916BO CSB-EP708916BO CSB-BP708916BO CSB-MP708916BO CSB-EP708916BO-B	Recombinant Bovine Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Nfe2l2 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP726674MO CSB-BP726674MO CSB-MP726674MO CSB-EP726674MO-B	Recombinant Mouse Nuclear factor erythroid 2-related factor 2 (Nfe2l2)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli