RBMS1
RBMS1，即RNA结合基序单链相互作用蛋白1，别名YC1、MSSP、SCR2、HCC-4、MSSP-1、MSSP-2、MSSP-3、C2orf12等。它是一种在人体中由RBMS1基因编码的蛋白质，属于RNA结合蛋白家族成员之一。RBMS1的作用机制涉及结合单链DNA/RNA，具有两个核糖核蛋白共有序列(RNP-CS)，含有保守基序RNP1和RNP2，这些基序最初在RNA结合蛋白中描述，并且对DNA结合是必需的。RBMS1参与多种生物学过程，包括DNA复制、基因转录、细胞周期进程和细胞凋亡 。RBMS1在生物学上的意义非常广泛，它不仅参与了基因表达的调控，还与肿瘤免疫逃逸、细胞转移和肿瘤抑制过程相关。例如，在三阴性乳腺癌中，RBMS1的下调能够阻断PD-L1免疫检查点，促进抗肿瘤免疫 。在非小细胞肺癌中，RBMS1与m6A阅读器YTHDF1相互作用，促进S100P的翻译，加速癌细胞的转移 。此外，RBMS1还通过调节SLC7A11的翻译控制调节肺癌铁死亡 。这些研究表明，RBMS1在肿瘤发展和转移中发挥着重要作用，是肿瘤治疗中的潜在靶点。
热销产品
RBMS1 Antibody (CSB-PA019440LA01HU)
验证数据
Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate
All lanes: RBMS1 antibody at 3.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 5 kDa
Observed band size: 45 kDa
Immunofluorescence staining of HepG2 cells with CSB-PA019440LA01HU at 1:120, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
RBMS1 Antibodies
RBMS1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA019440GA01HU | RBMS1 Antibody | Human,Mouse,Rat | ELISA,IF |
| CSB-PA145037 | RBMS1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA265034 | RBMS1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA019440LA01HU | RBMS1 Antibody | Human | ELISA, WB, IF |
| CSB-PA019440LB01HU | RBMS1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA019440LC01HU | RBMS1 Antibody, FITC conjugated | Human | |
| CSB-PA019440LD01HU | RBMS1 Antibody, Biotin conjugated | Human | ELISA |
RBMS1 Proteins
RBMS1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP019440HU CSB-EP019440HU CSB-BP019440HU CSB-MP019440HU CSB-EP019440HU-B |
Recombinant Human RNA-binding motif, single-stranded-interacting protein 1 (RBMS1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
