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SESN1

Sestrin-1 is a protein in humans that is encoded by SESN1 gene. Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway.

SESN1 Antibodies

SESN1 for Homo sapiens (Human)

SESN1 Proteins

SESN1 Proteins for Mus musculus (Mouse)

SESN1 Proteins for Xenopus laevis (African clawed frog)

SESN1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)