SLC6A6
SLC6A6(溶质载体家族6成员6)是一种重要的跨膜转运蛋白,负责牛磺酸的跨膜运输。它是一种多跨膜蛋白,通过钠离子和氯离子依赖性方式将牛磺酸运输进细胞内,对维持细胞内牛磺酸水平至关重要。SLC6A6的功能涉及细胞增殖和存活,其信号传导已证明能够影响这些细胞过程。SLC6A6参与的信号通路包括Wnt/β-Catenin信号通路,它通过减少活性氧(ROS)的产生和抑制该信号通路来抑制血管平滑肌细胞(VSMC)的增殖和迁移,维持VSMC的收缩表型,从而抑制新内膜形成。此外,SLC6A6在巨噬细胞中也发挥作用,其在M1巨噬细胞极化过程中的转录水平上调,影响巨噬细胞从M1到M2的重编程。SLC6A6的异常表达与多种疾病相关,包括视网膜变性、心肌病以及肿瘤进展,它在肿瘤微环境中的作用具有双重性,既能促进肿瘤细胞的恶性行为,也能增加CD8+ T细胞的存活和效应功能。因此,SLC6A6在调节免疫反应和肿瘤进展中起着重要作用,是研究和治疗相关疾病的潜在靶点。
热销产品
SLC6A6 Antibody (CSB-PA021704LA01HU)
验证数据
Western Blot
Positive WB detected in: PC-3 whole cell lysate, HL60 whole cell lysate,Mouse Brain tissue lysate,Mouse Liver tissue lysate
All lanes: SLC6A6 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa
Immunofluorescent analysis of MCF7 cells using CSB-PA021704LA01HU at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SLC6A6 Antibodies
SLC6A6 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA546856 | SLC6A6 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA050084 | SLC6A6 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA021704LA01HU | SLC6A6 Antibody | Human, Mouse | ELISA, WB, IF |
CSB-PA021704LB01HU | SLC6A6 Antibody, HRP conjugated | Human | ELISA |
CSB-PA021704LC01HU | SLC6A6 Antibody, FITC conjugated | Human | |
CSB-PA021704LD01HU | SLC6A6 Antibody, Biotin conjugated | Human | ELISA |
SLC6A6 Proteins
SLC6A6 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP021704HU CSB-EP021704HU CSB-BP021704HU CSB-MP021704HU CSB-EP021704HU-B |
Recombinant Human Sodium- and chloride-dependent taurine transporter (SLC6A6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |