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SMAD6

Mothers against decapentaplegic homolog 6 is a protein in humans that is encoded by SMAD6 gene. Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

SMAD6 Antibodies

SMAD6 for Homo sapiens (Human)

SMAD6 Proteins

SMAD6 Proteins for Mus musculus (Mouse)

SMAD6 Proteins for Homo sapiens (Human)

SMAD6 Proteins for Gallus gallus (Chicken)